Herpes simplex virus turns off the TAP to evade host immunity

Ann Hill, Pieter Jugovic, Lan York, Gustav Russ, Jack Bennink, Jonathan Yewdell, Hidde Ploegh, David Johnson

Research output: Contribution to journalLetter

698 Scopus citations

Abstract

MANY viruses have evolved mechanisms to avoid detection by the host immune system. Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks presentation of viral peptides to MHC class I-restricted cells1. The properties of the newly synthesized class I molecules in HSV-infected cells resemble those of cell lines deficient in the transporter associated with antigen processing (TAP) in that class I molecules are retained in the endoplasmic reticulum1, 2, and the heavy chain and β2-microglobulin subunits dissociate in detergent extracts but the complex can be stabilized by peptides1. We show here that ICP47 binds to TAP and prevents peptide translocation into the endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalNature
Volume375
Issue number6530
DOIs
StatePublished - Jun 1 1995

ASJC Scopus subject areas

  • General

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    Hill, A., Jugovic, P., York, L., Russ, G., Bennink, J., Yewdell, J., Ploegh, H., & Johnson, D. (1995). Herpes simplex virus turns off the TAP to evade host immunity. Nature, 375(6530), 411-415. https://doi.org/10.1038/375411a0