Herpes simplex virus turns off the TAP to evade host immunity

Ann Hill, Pieter Jugovic, Lan York, Gustav Russ, Jack Bennink, Jonathan Yewdell, Hidde Ploegh, David Johnson

Research output: Contribution to journalArticle

688 Citations (Scopus)

Abstract

MANY viruses have evolved mechanisms to avoid detection by the host immune system. Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks presentation of viral peptides to MHC class I-restricted cells1. The properties of the newly synthesized class I molecules in HSV-infected cells resemble those of cell lines deficient in the transporter associated with antigen processing (TAP) in that class I molecules are retained in the endoplasmic reticulum1,2, and the heavy chain and β2-microglobulin subunits dissociate in detergent extracts but the complex can be stabilized by peptides1. We show here that ICP47 binds to TAP and prevents peptide translocation into the endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalNature
Volume375
Issue number6530
StatePublished - 1995
Externally publishedYes

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trypsinogen activation peptide
Simplexvirus
Immunity
Immediate-Early Proteins
Complex Mixtures
Endoplasmic Reticulum
Detergents
Immune System
Viruses
Cell Line
Peptides
transporter associated with antigen processing (TAP)

ASJC Scopus subject areas

  • General

Cite this

Hill, A., Jugovic, P., York, L., Russ, G., Bennink, J., Yewdell, J., ... Johnson, D. (1995). Herpes simplex virus turns off the TAP to evade host immunity. Nature, 375(6530), 411-415.

Herpes simplex virus turns off the TAP to evade host immunity. / Hill, Ann; Jugovic, Pieter; York, Lan; Russ, Gustav; Bennink, Jack; Yewdell, Jonathan; Ploegh, Hidde; Johnson, David.

In: Nature, Vol. 375, No. 6530, 1995, p. 411-415.

Research output: Contribution to journalArticle

Hill, A, Jugovic, P, York, L, Russ, G, Bennink, J, Yewdell, J, Ploegh, H & Johnson, D 1995, 'Herpes simplex virus turns off the TAP to evade host immunity', Nature, vol. 375, no. 6530, pp. 411-415.
Hill A, Jugovic P, York L, Russ G, Bennink J, Yewdell J et al. Herpes simplex virus turns off the TAP to evade host immunity. Nature. 1995;375(6530):411-415.
Hill, Ann ; Jugovic, Pieter ; York, Lan ; Russ, Gustav ; Bennink, Jack ; Yewdell, Jonathan ; Ploegh, Hidde ; Johnson, David. / Herpes simplex virus turns off the TAP to evade host immunity. In: Nature. 1995 ; Vol. 375, No. 6530. pp. 411-415.
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