Herpes simplex virus brainstem encephalitis in an AIDS patient

R. L. Hamilton; C. Achim; M. R. Grafe; J. C. Fremont; D. Miners; C. A. Wiley

Herpes simplex virus brainstem encephalitis in an AIDS patient

R. L. Hamilton, C. Achim, M. R. Grafe, J. C. Fremont, D. Miners, C. A. Wiley

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of a virulent, atypical herpes simplex infection in the brainstem of a patient with Acquired Immune Deficiency Syndrome (AIDS) which was characterized by demyelination and oligodendroglial tropism. At autopsy the brainstem showed demyelination. Immunocytochemistry, in situ hybridization, and electron microscopy confirmed the presence of herpes simplex virus (HSV). Viral cultures demonstrated HSV type 1. Neuroinvasiveness and neurovirulence were studied by intraperitoneal inoculation of susceptible mouse strains (A/J and Balb/cByJ) with different viral titers. The LD₅₀ of the clinical isolate was 5 orders of magnitude greater than the LD₅₀ of a laboratory HSV strain (HSV type 1 KOS). The brains of the mice inoculated with the clinical isolate showed brainstem and cerebellar demyelination.

Original language	English (US)
Pages (from-to)	45-50
Number of pages	6
Journal	Clinical Neuropathology
Volume	14
Issue number	1
State	Published - 1995
Externally published	Yes

Keywords

Brainstem encephalitis
Herpes simplex virus

ASJC Scopus subject areas

Pathology and Forensic Medicine
Neurology
Clinical Neurology

Cite this

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AU - Hamilton, R. L.

AU - Achim, C.

AU - Grafe, M. R.

AU - Fremont, J. C.

AU - Miners, D.

AU - Wiley, C. A.

PY - 1995

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AB - We report a case of a virulent, atypical herpes simplex infection in the brainstem of a patient with Acquired Immune Deficiency Syndrome (AIDS) which was characterized by demyelination and oligodendroglial tropism. At autopsy the brainstem showed demyelination. Immunocytochemistry, in situ hybridization, and electron microscopy confirmed the presence of herpes simplex virus (HSV). Viral cultures demonstrated HSV type 1. Neuroinvasiveness and neurovirulence were studied by intraperitoneal inoculation of susceptible mouse strains (A/J and Balb/cByJ) with different viral titers. The LD50 of the clinical isolate was 5 orders of magnitude greater than the LD50 of a laboratory HSV strain (HSV type 1 KOS). The brains of the mice inoculated with the clinical isolate showed brainstem and cerebellar demyelination.

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Herpes simplex virus brainstem encephalitis in an AIDS patient

Abstract

Keywords

ASJC Scopus subject areas

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