Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen

Lynne Morrison, R. S. Labib, J. J. Zone, L. A. Diaz, G. J. Anhalt

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Herpes gestationis (HG) is a putative autoimmune bullous dermatosis of pregnancy which shares many findings with bullous pemphigoid (BP), a disease of the elderly. This study identifies for the first time the antigen detected by HG autoantibodies and compares it with that recognized by BP autoantibodies. Sera from 16 HG and 17 BP patients, and from normal pregnant women were evaluated by immunofluorescent (IF) studies and immunoblotted against human epidermal extracts. 89% of HG sera with circulating antibodies by IF recognized a 180-kD protein by immunoblotting. 71% of BP sera recognized a 240-kD band, but 47% detected a 180-kD protein that comigrated with the antigen detected by HG sera. None of the control sera recognized any specific bands. These findings suggest that the 180-kD epidermal protein may be the antigen detected by the HG factor and they also define immunologic similarities between HG and BP.

Original languageEnglish (US)
Pages (from-to)2023-2026
Number of pages4
JournalJournal of Clinical Investigation
Volume81
Issue number6
StatePublished - 1988
Externally publishedYes

Fingerprint

Pemphigoid Gestationis
Autoantibodies
Bullous Pemphigoid
Antigens
Serum
Vesiculobullous Skin Diseases
Proteins
Immunoblotting
Pregnant Women
Pregnancy
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morrison, L., Labib, R. S., Zone, J. J., Diaz, L. A., & Anhalt, G. J. (1988). Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen. Journal of Clinical Investigation, 81(6), 2023-2026.

Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen. / Morrison, Lynne; Labib, R. S.; Zone, J. J.; Diaz, L. A.; Anhalt, G. J.

In: Journal of Clinical Investigation, Vol. 81, No. 6, 1988, p. 2023-2026.

Research output: Contribution to journalArticle

Morrison, L, Labib, RS, Zone, JJ, Diaz, LA & Anhalt, GJ 1988, 'Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen', Journal of Clinical Investigation, vol. 81, no. 6, pp. 2023-2026.
Morrison, Lynne ; Labib, R. S. ; Zone, J. J. ; Diaz, L. A. ; Anhalt, G. J. / Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen. In: Journal of Clinical Investigation. 1988 ; Vol. 81, No. 6. pp. 2023-2026.
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