Herpes gestationis

Lynne Morrison, Grant J. Anhalt

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Herpes gestationis is a rare, self limited bullous disease of pregnancy and the post-partum period with a presumed autoimmune basis. It is characterized clinically by pruritic, urticarial and vesiculobullous lesions, histologically by subepidermal vesicle formation, and immunopathologically by deposition of immunoreactants along the basement membrane zone. These features are shared by bullous pemphigoid which suggests that herpes gestationis may be a related entity. Immunoblotting studies have shown that herpes gestationis sera recognize a 180 kD epidermal antigen; in comparison, bullous pemphigoid sera most often detect a 220-240 kD antigen, but a significant number also recognize a 180 kD epidermal antigen, suggesting immunological similarities between these two diseases. Etiology and pathophysiology are not established, but an immunological basis is implicated by the frequent finding of C3 along the basement membrane zone of perilesional skin, the presence of herpes gestationis factor, increased incidence of HLA-DR3 and HLA-DR4, and association with other putative autoimmune diseases. Treatment usually consists of systemic corticosteroids.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalJournal of Autoimmunity
Volume4
Issue number1
DOIs
StatePublished - 1991

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Pemphigoid Gestationis
Bullous Pemphigoid
Antigens
Basement Membrane
HLA-DR3 Antigen
HLA-DR4 Antigen
Serum
Immunoblotting
Autoimmune Diseases
Adrenal Cortex Hormones
Pregnancy
Skin
Incidence

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Herpes gestationis. / Morrison, Lynne; Anhalt, Grant J.

In: Journal of Autoimmunity, Vol. 4, No. 1, 1991, p. 37-45.

Research output: Contribution to journalArticle

Morrison, Lynne ; Anhalt, Grant J. / Herpes gestationis. In: Journal of Autoimmunity. 1991 ; Vol. 4, No. 1. pp. 37-45.
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