Heritability of the human connectome: A connectotyping study

Oscar Miranda-Dominguez, Eric Feczko, David S. Grayson, Hasse Walum, Joel T. Nigg, Damien A. Fair

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Recent progress in resting-state neuroimaging demonstrates that the brain exhibits highly individualized patterns of functional connectivity—a “connectotype.” How these individualized patterns may be constrained by environment and genetics is unknown. Here we ask whether the connectotype is familial and heritable. Using a novel approach to estimate familiality via a machine-learning framework, we analyzed resting-state fMRI scans from two well-characterized samples of child and adult siblings. First we show that individual connectotypes were reliably identified even several years after the initial scanning timepoint. Familial relationships between participants, such as siblings versus those who are unrelated, were also accurately characterized. The connectotype demonstrated substantial heritability driven by high-order systems including the fronto-parietal, dorsal attention, ventral attention, cingulo-opercular, and default systems. This work suggests that shared genetics and environment contribute toward producing complex, individualized patterns of distributed brain activity, rather than constraining local aspects of function. These insights offer new strategies for characterizing individual aberrations in brain function and evaluating heritability of brain networks.

Original languageEnglish (US)
Pages (from-to)175-199
Number of pages25
JournalNetwork Neuroscience
Volume2
Issue number2
DOIs
StatePublished - Jan 1 2017

Fingerprint

Connectome
Heritability
Brain
Siblings
Neuroimaging
Functional Magnetic Resonance Imaging
Aberrations
Aberration
Learning systems
Scanning
Machine Learning
Magnetic Resonance Imaging
Higher Order
Unknown
Human
Estimate
Demonstrate

Keywords

  • Development
  • Effective connectivity
  • Functional connectivity
  • Heritability
  • MRI
  • Resting-state MRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Computer Science Applications
  • Artificial Intelligence
  • Applied Mathematics

Cite this

Heritability of the human connectome : A connectotyping study. / Miranda-Dominguez, Oscar; Feczko, Eric; Grayson, David S.; Walum, Hasse; Nigg, Joel T.; Fair, Damien A.

In: Network Neuroscience, Vol. 2, No. 2, 01.01.2017, p. 175-199.

Research output: Contribution to journalArticle

Miranda-Dominguez, O, Feczko, E, Grayson, DS, Walum, H, Nigg, JT & Fair, DA 2017, 'Heritability of the human connectome: A connectotyping study', Network Neuroscience, vol. 2, no. 2, pp. 175-199. https://doi.org/10.1162/netn_a_00029
Miranda-Dominguez, Oscar ; Feczko, Eric ; Grayson, David S. ; Walum, Hasse ; Nigg, Joel T. ; Fair, Damien A. / Heritability of the human connectome : A connectotyping study. In: Network Neuroscience. 2017 ; Vol. 2, No. 2. pp. 175-199.
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