TY - JOUR
T1 - Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India
AU - Reddy, P. H.
AU - Petrou, M.
AU - Reddy, P. A.
AU - Tiwary, R. S.
AU - Modell, B.
PY - 1995/8
Y1 - 1995/8
N2 - Abstract: We have studied the prevalence and molecular nature of hereditary anaemias (abnormal haemoglobins, β‐thalassaemia, α‐thalassaemia, and Glucose 6 phosphate dehydrogenase (G6PD) deficiency) in a primitive central Indian tribe, the Baiga. 43% of the population appear to be iron‐deficient. Hereditary anaemia gene frequencies are, sickle cell 0.0824, G6PD deficiency (in males) 0.0457, β‐thalassaemia 0.0057, and deletional α‐plus thalassaemia 0.65. Both – α3.7 and –α4.2 deletions were observed and non‐deletional α‐thalassaemia was suspected. The overall gene frequency of Xmn I + polymorphism (C→T – 158 cap site; upstream of G gamma region) is 0.35. This polymorphism is preferentially linked to βS genes. It appears that sickle cell disease covers a wide range of severity in the Baiga tribe based on higher mortality in the offspring of AS × AS parents (2.5/couple) compared to AA × AS (0.75/couple) and AA × AA (0.76/couple) parents. This is compatible with the high frequency of genetic modifying factors, i.e., the Xmn I polymorphism and α‐thalassaemia. The results also indicate that “normal” red cell values must be defined for each population where thalassaemias, G6PD deficiency and iron deficiency are common.
AB - Abstract: We have studied the prevalence and molecular nature of hereditary anaemias (abnormal haemoglobins, β‐thalassaemia, α‐thalassaemia, and Glucose 6 phosphate dehydrogenase (G6PD) deficiency) in a primitive central Indian tribe, the Baiga. 43% of the population appear to be iron‐deficient. Hereditary anaemia gene frequencies are, sickle cell 0.0824, G6PD deficiency (in males) 0.0457, β‐thalassaemia 0.0057, and deletional α‐plus thalassaemia 0.65. Both – α3.7 and –α4.2 deletions were observed and non‐deletional α‐thalassaemia was suspected. The overall gene frequency of Xmn I + polymorphism (C→T – 158 cap site; upstream of G gamma region) is 0.35. This polymorphism is preferentially linked to βS genes. It appears that sickle cell disease covers a wide range of severity in the Baiga tribe based on higher mortality in the offspring of AS × AS parents (2.5/couple) compared to AA × AS (0.75/couple) and AA × AA (0.76/couple) parents. This is compatible with the high frequency of genetic modifying factors, i.e., the Xmn I polymorphism and α‐thalassaemia. The results also indicate that “normal” red cell values must be defined for each population where thalassaemias, G6PD deficiency and iron deficiency are common.
KW - Indian tribal peoples
KW - Xmn I polymorphism
KW - alpha thalassaemia
KW - sickle cell
UR - http://www.scopus.com/inward/record.url?scp=0029086602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029086602&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0609.1995.tb01818.x
DO - 10.1111/j.1600-0609.1995.tb01818.x
M3 - Article
C2 - 7628584
AN - SCOPUS:0029086602
VL - 55
SP - 103
EP - 109
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 2
ER -