Abstract
We have studied the prevalence and molecular nature of hereditary anaemias (abnormal haemoglobins, β-thalassaemia, β-thalassaemia, and Glucose 6 phosphate dehydrogenase (G6PD) deficiency) in a primitive central Indian tribe, the Baiga. 43% of the population appear to be iron-deficient. Hereditary anaemia gene frequencies are, sickle cell 0.0824, G6PD deficiency (in males) 0.0457, β-thalassaemia 0.0057, and deletional α-plus thalassaemia 0.65. Both - α3.7 and - α4.2 deletions were observed and non-deletional α-thalassaemia was suspected. The overall gene frequency of Xmn I + polymorphism (C → T - 158 cap site; upstream of G gamma region) is 0.35. This polymorphism is preferentially linked to β(S) genes. It appears that sickle cell disease covers a wide range of severity in the Baiga tribe based on higher mortality in the offspring of AS x AS parents (2.5/couple) compared to AA x AS (0.75/couple) and AA x AA (0.76/couple) parents. This is compatible with the high frequency of genetic modifying factors, i.e., the Xmn I polymorphism and cl-thalassaemia. The results also indicate that 'normal' red cell values must be defined for each population where thalassaemias, G6PD deficiency and iron deficiency are common.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-109 |
| Number of pages | 7 |
| Journal | European Journal of Haematology |
| Volume | 55 |
| Issue number | 2 |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- Alpha thalassaemia
- Indian tribal peoples
- Sickle cell
- Xmn I polymorphism
ASJC Scopus subject areas
- Hematology
Cite this
Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India. / Reddy, P (Hemachandra); Petrou, M.; Rddy, P. A.; Tiwary, R. S.; Modell, B.
In: European Journal of Haematology, Vol. 55, No. 2, 1995, p. 103-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India
AU - Reddy, P (Hemachandra)
AU - Petrou, M.
AU - Rddy, P. A.
AU - Tiwary, R. S.
AU - Modell, B.
PY - 1995
Y1 - 1995
N2 - We have studied the prevalence and molecular nature of hereditary anaemias (abnormal haemoglobins, β-thalassaemia, β-thalassaemia, and Glucose 6 phosphate dehydrogenase (G6PD) deficiency) in a primitive central Indian tribe, the Baiga. 43% of the population appear to be iron-deficient. Hereditary anaemia gene frequencies are, sickle cell 0.0824, G6PD deficiency (in males) 0.0457, β-thalassaemia 0.0057, and deletional α-plus thalassaemia 0.65. Both - α3.7 and - α4.2 deletions were observed and non-deletional α-thalassaemia was suspected. The overall gene frequency of Xmn I + polymorphism (C → T - 158 cap site; upstream of G gamma region) is 0.35. This polymorphism is preferentially linked to β(S) genes. It appears that sickle cell disease covers a wide range of severity in the Baiga tribe based on higher mortality in the offspring of AS x AS parents (2.5/couple) compared to AA x AS (0.75/couple) and AA x AA (0.76/couple) parents. This is compatible with the high frequency of genetic modifying factors, i.e., the Xmn I polymorphism and cl-thalassaemia. The results also indicate that 'normal' red cell values must be defined for each population where thalassaemias, G6PD deficiency and iron deficiency are common.
AB - We have studied the prevalence and molecular nature of hereditary anaemias (abnormal haemoglobins, β-thalassaemia, β-thalassaemia, and Glucose 6 phosphate dehydrogenase (G6PD) deficiency) in a primitive central Indian tribe, the Baiga. 43% of the population appear to be iron-deficient. Hereditary anaemia gene frequencies are, sickle cell 0.0824, G6PD deficiency (in males) 0.0457, β-thalassaemia 0.0057, and deletional α-plus thalassaemia 0.65. Both - α3.7 and - α4.2 deletions were observed and non-deletional α-thalassaemia was suspected. The overall gene frequency of Xmn I + polymorphism (C → T - 158 cap site; upstream of G gamma region) is 0.35. This polymorphism is preferentially linked to β(S) genes. It appears that sickle cell disease covers a wide range of severity in the Baiga tribe based on higher mortality in the offspring of AS x AS parents (2.5/couple) compared to AA x AS (0.75/couple) and AA x AA (0.76/couple) parents. This is compatible with the high frequency of genetic modifying factors, i.e., the Xmn I polymorphism and cl-thalassaemia. The results also indicate that 'normal' red cell values must be defined for each population where thalassaemias, G6PD deficiency and iron deficiency are common.
KW - Alpha thalassaemia
KW - Indian tribal peoples
KW - Sickle cell
KW - Xmn I polymorphism
UR - http://www.scopus.com/inward/record.url?scp=0029086602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029086602&partnerID=8YFLogxK
M3 - Article
C2 - 7628584
AN - SCOPUS:0029086602
VL - 55
SP - 103
EP - 109
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 2
ER -