Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India

P (Hemachandra) Reddy, M. Petrou, P. A. Rddy, R. S. Tiwary, B. Modell

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We have studied the prevalence and molecular nature of hereditary anaemias (abnormal haemoglobins, β-thalassaemia, β-thalassaemia, and Glucose 6 phosphate dehydrogenase (G6PD) deficiency) in a primitive central Indian tribe, the Baiga. 43% of the population appear to be iron-deficient. Hereditary anaemia gene frequencies are, sickle cell 0.0824, G6PD deficiency (in males) 0.0457, β-thalassaemia 0.0057, and deletional α-plus thalassaemia 0.65. Both - α3.7 and - α4.2 deletions were observed and non-deletional α-thalassaemia was suspected. The overall gene frequency of Xmn I + polymorphism (C → T - 158 cap site; upstream of G gamma region) is 0.35. This polymorphism is preferentially linked to β(S) genes. It appears that sickle cell disease covers a wide range of severity in the Baiga tribe based on higher mortality in the offspring of AS x AS parents (2.5/couple) compared to AA x AS (0.75/couple) and AA x AA (0.76/couple) parents. This is compatible with the high frequency of genetic modifying factors, i.e., the Xmn I polymorphism and cl-thalassaemia. The results also indicate that 'normal' red cell values must be defined for each population where thalassaemias, G6PD deficiency and iron deficiency are common.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalEuropean Journal of Haematology
Volume55
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Thalassemia
Iron-Deficiency Anemias
India
Glucosephosphate Dehydrogenase Deficiency
Population
Gene Frequency
Anemia
Iron
Abnormal Hemoglobins
Sickle Cell Anemia
Mortality
Genes

Keywords

  • Alpha thalassaemia
  • Indian tribal peoples
  • Sickle cell
  • Xmn I polymorphism

ASJC Scopus subject areas

  • Hematology

Cite this

Reddy, P. H., Petrou, M., Rddy, P. A., Tiwary, R. S., & Modell, B. (1995). Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India. European Journal of Haematology, 55(2), 103-109.

Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India. / Reddy, P (Hemachandra); Petrou, M.; Rddy, P. A.; Tiwary, R. S.; Modell, B.

In: European Journal of Haematology, Vol. 55, No. 2, 1995, p. 103-109.

Research output: Contribution to journalArticle

Reddy, PH, Petrou, M, Rddy, PA, Tiwary, RS & Modell, B 1995, 'Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India', European Journal of Haematology, vol. 55, no. 2, pp. 103-109.
Reddy, P (Hemachandra) ; Petrou, M. ; Rddy, P. A. ; Tiwary, R. S. ; Modell, B. / Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India. In: European Journal of Haematology. 1995 ; Vol. 55, No. 2. pp. 103-109.
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