Hepatocyte versus biliary disease: A distinction by deconvolutional analysis of technetium-99m IDA time-activity curves

Paul Brown, J. E. Juni, David Lieberman, G. T. Krishnamurthy

Research output: Contribution to journalArticle

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Abstract

A combination of quantitative hepatobiliary imaging techniques was developed study normal control subjects and patients with 3 categories of hepatobiliary disease: 1) alcoholic cirrhosis; 2) sclerosing cholangitis; and 3) isolated common bile duct obstruction. Scintigraphic images were supplemented by quantitative measurement of hepatic extraction fraction by deconvolutional analysis and liver excretion T( 1/2 ) by a nonlinear least squares method. In diseases confined primarily to the biliary tract (isolated common bile duct obstruction and sclerosing cholangitis), the mean hepatic extraction fraction as measured by deconvolutional analysis was not different from that in normal controls. In severe alcoholic cirrhosis, considered primarily a hepatocyte disease, the hepatic extraction fraction was markedly reduced. The T( 1/2 ) excretion, compared to normal subjects, was prolonged in all three liver disease categories. We conclude that these quantitative parameters were able to detect hepatobiliary disease and to separate severe hepatocyte disease from biliary tract disease.

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalJournal of Nuclear Medicine
Volume29
Issue number5
StatePublished - 1988

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Technetium
Hepatocytes
Alcoholic Liver Cirrhosis
Sclerosing Cholangitis
Liver
Cholestasis
Common Bile Duct
Biliary Tract Diseases
Biliary Tract
Least-Squares Analysis
Liver Diseases

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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Hepatocyte versus biliary disease : A distinction by deconvolutional analysis of technetium-99m IDA time-activity curves. / Brown, Paul; Juni, J. E.; Lieberman, David; Krishnamurthy, G. T.

In: Journal of Nuclear Medicine, Vol. 29, No. 5, 1988, p. 623-630.

Research output: Contribution to journalArticle

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