Abstract
Hepatitis D virus causes an aggressive viral hepatitis with a virulent course of progression to cirrhosis and hepatic decompensation. It relies on hepatitis B coinfection for its pathogenesis and propagation. Hepatitis D virus had become the forgotten virus, with reduced public awareness, medical interest, and research support. Recently, there has been a resurgence of awareness and interest in hepatitis D, with improvements in diagnostic testing and establishment of international collaborative efforts to improve therapy. This article provides a framework to understand the impetus for increased screening as well as to identify key issues toward which collaborative efforts can be directed.
Original language | English (US) |
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Pages (from-to) | 647-686 |
Number of pages | 40 |
Journal | Gastroenterology and Hepatology |
Volume | 10 |
Issue number | 10 |
State | Published - Oct 1 2014 |
Keywords
- Cirrhosis
- Hepatitis delta
- Interferon
- Pegylated interferon
- Prenylation inhibitors
ASJC Scopus subject areas
- Hepatology
- Gastroenterology