Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation

H. R. Rosen, D. J. Hinrichs, R. L. Leistikow, G. Callender, A. M. Wertheimer, M. I. Nishimura, David Lewinsohn, George M. Lauer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

By necessity, human liver transplantation is performed across HLA barriers. As a result, intracellular infection of the allograft presents a unique immunologic challenge for the recipient's immune system. In this study, we describe the presence of HLA-A2-restricted, hepatitis C virus (HCV)-specific CD8+ T cells in liver transplant recipients in whom the allograft is HLA-A2 positive and the recipient is HLA-A2 negative. These memory-effector T cells are recipient derived and recognize HCV peptide uniquely in the context of HLA-A2. Furthermore, these cells were absent before the transplant, suggesting that the allograft is capable of selectively expanding naive CD8+ T cells. The in vitro specificity to donor HLA allele-restricted CD8+ T cells suggests that these cells may function to control HCV spread in the allograft.

Original languageEnglish (US)
Pages (from-to)848-850
Number of pages3
JournalLiver Transplantation
Volume11
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

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HLA-A2 Antigen
Hepacivirus
Liver Transplantation
Allografts
Alleles
Tissue Donors
T-Lymphocytes
Immune System
Transplants
Peptides
Liver
Infection

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Rosen, H. R., Hinrichs, D. J., Leistikow, R. L., Callender, G., Wertheimer, A. M., Nishimura, M. I., ... Lauer, G. M. (2005). Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. Liver Transplantation, 11(7), 848-850. https://doi.org/10.1002/lt.20423

Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. / Rosen, H. R.; Hinrichs, D. J.; Leistikow, R. L.; Callender, G.; Wertheimer, A. M.; Nishimura, M. I.; Lewinsohn, David; Lauer, George M.

In: Liver Transplantation, Vol. 11, No. 7, 07.2005, p. 848-850.

Research output: Contribution to journalArticle

Rosen, HR, Hinrichs, DJ, Leistikow, RL, Callender, G, Wertheimer, AM, Nishimura, MI, Lewinsohn, D & Lauer, GM 2005, 'Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation', Liver Transplantation, vol. 11, no. 7, pp. 848-850. https://doi.org/10.1002/lt.20423
Rosen HR, Hinrichs DJ, Leistikow RL, Callender G, Wertheimer AM, Nishimura MI et al. Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. Liver Transplantation. 2005 Jul;11(7):848-850. https://doi.org/10.1002/lt.20423
Rosen, H. R. ; Hinrichs, D. J. ; Leistikow, R. L. ; Callender, G. ; Wertheimer, A. M. ; Nishimura, M. I. ; Lewinsohn, David ; Lauer, George M. / Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. In: Liver Transplantation. 2005 ; Vol. 11, No. 7. pp. 848-850.
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