Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients

Jordana L. Soule, Ali J. Olyaei, Tobin A. Boslaugh, Ann M H Busch, Jonathan M. Schwartz, Samuel H. Morehouse, John M. Ham, Susan Orloff, Patrick J. Healey

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Recent evidence suggests that new-onset diabetes after transplant (NODAT) adversely affects orthotopic liver transplant (OLTX) patient and graft survival. The objective of this study is to evaluate the effect of hepatitis C infection on the natural history of NODAT. Methods: A retrospective review of 492 OLTX recipients at a single center was conducted from January 1993 to January 2003. Patients were followed for a minimum of 12 months (range 12 months-10 years). The study population consisted of 444 OLTX recipients who were either HCV positive (n = 206) or HCV negative (n = 238). NODAT was defined by the need for antidiabetic medication for at least 7 days starting anytime after OLTX. Statistical analysis was performed by using the Student t test, Kaplan-Meier survival, and chi-square tests. Results: The overall incidence of NODAT was 33% (146/444). There was a significant difference in the development of NODAT between the HCV-positive group (82/206, 40%) and the HCV-negative group (64/238, 27%) (P <.001). Other independent risk factors for development of NODAT were male gender and age >50 years. Conclusion: Hepatitis C infection contributes to the development of diabetes mellitus in OLTX recipients. The mechanisms behind HCV infection and associated NODAT in HCV-positive OLTX recipients warrant further investigation.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalAmerican Journal of Surgery
Volume189
Issue number5 SPEC. ISS.
DOIs
StatePublished - May 2005

Fingerprint

Hepatitis C
Liver Transplantation
Allografts
Transplants
Infection
Kaplan-Meier Estimate
Graft Survival
Chi-Square Distribution
Natural History
Hypoglycemic Agents
Diabetes Mellitus
Students
Survival
Liver
Incidence
Population

Keywords

  • Hepatitis C infection
  • Liver transplantation
  • New-onset diabetes after transplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Soule, J. L., Olyaei, A. J., Boslaugh, T. A., Busch, A. M. H., Schwartz, J. M., Morehouse, S. H., ... Healey, P. J. (2005). Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients. American Journal of Surgery, 189(5 SPEC. ISS.), 552-557. https://doi.org/10.1016/j.amjsurg.2005.01.033

Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients. / Soule, Jordana L.; Olyaei, Ali J.; Boslaugh, Tobin A.; Busch, Ann M H; Schwartz, Jonathan M.; Morehouse, Samuel H.; Ham, John M.; Orloff, Susan; Healey, Patrick J.

In: American Journal of Surgery, Vol. 189, No. 5 SPEC. ISS., 05.2005, p. 552-557.

Research output: Contribution to journalArticle

Soule, JL, Olyaei, AJ, Boslaugh, TA, Busch, AMH, Schwartz, JM, Morehouse, SH, Ham, JM, Orloff, S & Healey, PJ 2005, 'Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients', American Journal of Surgery, vol. 189, no. 5 SPEC. ISS., pp. 552-557. https://doi.org/10.1016/j.amjsurg.2005.01.033
Soule, Jordana L. ; Olyaei, Ali J. ; Boslaugh, Tobin A. ; Busch, Ann M H ; Schwartz, Jonathan M. ; Morehouse, Samuel H. ; Ham, John M. ; Orloff, Susan ; Healey, Patrick J. / Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients. In: American Journal of Surgery. 2005 ; Vol. 189, No. 5 SPEC. ISS. pp. 552-557.
@article{8455b2bf422b431aa4562051bb5cf876,
title = "Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients",
abstract = "Background: Recent evidence suggests that new-onset diabetes after transplant (NODAT) adversely affects orthotopic liver transplant (OLTX) patient and graft survival. The objective of this study is to evaluate the effect of hepatitis C infection on the natural history of NODAT. Methods: A retrospective review of 492 OLTX recipients at a single center was conducted from January 1993 to January 2003. Patients were followed for a minimum of 12 months (range 12 months-10 years). The study population consisted of 444 OLTX recipients who were either HCV positive (n = 206) or HCV negative (n = 238). NODAT was defined by the need for antidiabetic medication for at least 7 days starting anytime after OLTX. Statistical analysis was performed by using the Student t test, Kaplan-Meier survival, and chi-square tests. Results: The overall incidence of NODAT was 33{\%} (146/444). There was a significant difference in the development of NODAT between the HCV-positive group (82/206, 40{\%}) and the HCV-negative group (64/238, 27{\%}) (P <.001). Other independent risk factors for development of NODAT were male gender and age >50 years. Conclusion: Hepatitis C infection contributes to the development of diabetes mellitus in OLTX recipients. The mechanisms behind HCV infection and associated NODAT in HCV-positive OLTX recipients warrant further investigation.",
keywords = "Hepatitis C infection, Liver transplantation, New-onset diabetes after transplantation",
author = "Soule, {Jordana L.} and Olyaei, {Ali J.} and Boslaugh, {Tobin A.} and Busch, {Ann M H} and Schwartz, {Jonathan M.} and Morehouse, {Samuel H.} and Ham, {John M.} and Susan Orloff and Healey, {Patrick J.}",
year = "2005",
month = "5",
doi = "10.1016/j.amjsurg.2005.01.033",
language = "English (US)",
volume = "189",
pages = "552--557",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "5 SPEC. ISS.",

}

TY - JOUR

T1 - Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients

AU - Soule, Jordana L.

AU - Olyaei, Ali J.

AU - Boslaugh, Tobin A.

AU - Busch, Ann M H

AU - Schwartz, Jonathan M.

AU - Morehouse, Samuel H.

AU - Ham, John M.

AU - Orloff, Susan

AU - Healey, Patrick J.

PY - 2005/5

Y1 - 2005/5

N2 - Background: Recent evidence suggests that new-onset diabetes after transplant (NODAT) adversely affects orthotopic liver transplant (OLTX) patient and graft survival. The objective of this study is to evaluate the effect of hepatitis C infection on the natural history of NODAT. Methods: A retrospective review of 492 OLTX recipients at a single center was conducted from January 1993 to January 2003. Patients were followed for a minimum of 12 months (range 12 months-10 years). The study population consisted of 444 OLTX recipients who were either HCV positive (n = 206) or HCV negative (n = 238). NODAT was defined by the need for antidiabetic medication for at least 7 days starting anytime after OLTX. Statistical analysis was performed by using the Student t test, Kaplan-Meier survival, and chi-square tests. Results: The overall incidence of NODAT was 33% (146/444). There was a significant difference in the development of NODAT between the HCV-positive group (82/206, 40%) and the HCV-negative group (64/238, 27%) (P <.001). Other independent risk factors for development of NODAT were male gender and age >50 years. Conclusion: Hepatitis C infection contributes to the development of diabetes mellitus in OLTX recipients. The mechanisms behind HCV infection and associated NODAT in HCV-positive OLTX recipients warrant further investigation.

AB - Background: Recent evidence suggests that new-onset diabetes after transplant (NODAT) adversely affects orthotopic liver transplant (OLTX) patient and graft survival. The objective of this study is to evaluate the effect of hepatitis C infection on the natural history of NODAT. Methods: A retrospective review of 492 OLTX recipients at a single center was conducted from January 1993 to January 2003. Patients were followed for a minimum of 12 months (range 12 months-10 years). The study population consisted of 444 OLTX recipients who were either HCV positive (n = 206) or HCV negative (n = 238). NODAT was defined by the need for antidiabetic medication for at least 7 days starting anytime after OLTX. Statistical analysis was performed by using the Student t test, Kaplan-Meier survival, and chi-square tests. Results: The overall incidence of NODAT was 33% (146/444). There was a significant difference in the development of NODAT between the HCV-positive group (82/206, 40%) and the HCV-negative group (64/238, 27%) (P <.001). Other independent risk factors for development of NODAT were male gender and age >50 years. Conclusion: Hepatitis C infection contributes to the development of diabetes mellitus in OLTX recipients. The mechanisms behind HCV infection and associated NODAT in HCV-positive OLTX recipients warrant further investigation.

KW - Hepatitis C infection

KW - Liver transplantation

KW - New-onset diabetes after transplantation

UR - http://www.scopus.com/inward/record.url?scp=18044382900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18044382900&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2005.01.033

DO - 10.1016/j.amjsurg.2005.01.033

M3 - Article

VL - 189

SP - 552

EP - 557

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 5 SPEC. ISS.

ER -