Hepatitis A and hepatitis B infection prevalence and associated risk factors in men who have sex with men, Bangkok, 2006-2008

Robert W. Linkins, Wannee Chonwattana, Timothy H. Holtz, Punneeporn Wasinrapee, Supaporn Chaikummao, Anchalee Varangrat, Jaray Tongtoyai, Philip A. Mock, Marcel Curlin, Pachara Sirivongrangson, Frits van Griensven, Janet M. Mcnicholl

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Despite the availability of safe and effective vaccines, little is known about prevalence and risk factors for hepatitis A (HAV) and hepatitis B virus (HBV) infection among Thai men who have sex with men. The prevalence of HAV and HBV infection among men who have sex with men cohort in Bangkok was assessed. Baseline blood specimens were drawn and demographic and behavioral data were collected. Bivariate and multivariate logistic regression analysis was used to analyze risk factors for prevalent HAV and HBV infection. One thousand two hundred ninety-nine Thai men who have sex with men 18 years and older were enrolled. Among those with results, 349/1,291 (27.0%) had evidence of past or current hepatitis A infection. Of the 1,117 (86.5%) men with unambiguous HBV test results, 442 (39.6%) had serologic evidence of past/current infection, 103 (9.2%) were immune due to hepatitis B vaccination, 572 (51.2%) had no evidence of immunological exposure to HBV or vaccine. Of those with past/current HBV infection, 130 (29.4%) were HIV positive. Age >35 years was independently associated with both HAV and HBV infection. University education was protective against both HAV and HBV infection. Increased alcohol consumption, number of lifetime male sexual partners ≥10, and prevalent HIV infection were also independently associated with HBV infection. The prevalence of past/current HAV and HBV infection was high in Bangkok men who have sex with men. Age-cohorts with a higher prevalence of hepatitis B vaccine induced immunity may be expected in the future. Hepatitis A and B vaccination is recommended.

Original languageEnglish (US)
Pages (from-to)1499-1505
Number of pages7
JournalJournal of Medical Virology
Volume85
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Hepatitis A
Hepatitis B
Hepatitis B virus
Virus Diseases
Infection
Hepatitis B Vaccines
Vaccination
Sexual Partners
Alcohol Drinking
HIV Infections
Immunity
Vaccines
Logistic Models
Regression Analysis
Demography
HIV
Education

Keywords

  • Hepatitis A
  • Hepatitis B
  • Homosexual men
  • Immunization
  • Prevalence
  • Risk factors
  • Thailand

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Linkins, R. W., Chonwattana, W., Holtz, T. H., Wasinrapee, P., Chaikummao, S., Varangrat, A., ... Mcnicholl, J. M. (2013). Hepatitis A and hepatitis B infection prevalence and associated risk factors in men who have sex with men, Bangkok, 2006-2008. Journal of Medical Virology, 85(9), 1499-1505. https://doi.org/10.1002/jmv.23637

Hepatitis A and hepatitis B infection prevalence and associated risk factors in men who have sex with men, Bangkok, 2006-2008. / Linkins, Robert W.; Chonwattana, Wannee; Holtz, Timothy H.; Wasinrapee, Punneeporn; Chaikummao, Supaporn; Varangrat, Anchalee; Tongtoyai, Jaray; Mock, Philip A.; Curlin, Marcel; Sirivongrangson, Pachara; van Griensven, Frits; Mcnicholl, Janet M.

In: Journal of Medical Virology, Vol. 85, No. 9, 09.2013, p. 1499-1505.

Research output: Contribution to journalArticle

Linkins, RW, Chonwattana, W, Holtz, TH, Wasinrapee, P, Chaikummao, S, Varangrat, A, Tongtoyai, J, Mock, PA, Curlin, M, Sirivongrangson, P, van Griensven, F & Mcnicholl, JM 2013, 'Hepatitis A and hepatitis B infection prevalence and associated risk factors in men who have sex with men, Bangkok, 2006-2008', Journal of Medical Virology, vol. 85, no. 9, pp. 1499-1505. https://doi.org/10.1002/jmv.23637
Linkins, Robert W. ; Chonwattana, Wannee ; Holtz, Timothy H. ; Wasinrapee, Punneeporn ; Chaikummao, Supaporn ; Varangrat, Anchalee ; Tongtoyai, Jaray ; Mock, Philip A. ; Curlin, Marcel ; Sirivongrangson, Pachara ; van Griensven, Frits ; Mcnicholl, Janet M. / Hepatitis A and hepatitis B infection prevalence and associated risk factors in men who have sex with men, Bangkok, 2006-2008. In: Journal of Medical Virology. 2013 ; Vol. 85, No. 9. pp. 1499-1505.
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abstract = "Despite the availability of safe and effective vaccines, little is known about prevalence and risk factors for hepatitis A (HAV) and hepatitis B virus (HBV) infection among Thai men who have sex with men. The prevalence of HAV and HBV infection among men who have sex with men cohort in Bangkok was assessed. Baseline blood specimens were drawn and demographic and behavioral data were collected. Bivariate and multivariate logistic regression analysis was used to analyze risk factors for prevalent HAV and HBV infection. One thousand two hundred ninety-nine Thai men who have sex with men 18 years and older were enrolled. Among those with results, 349/1,291 (27.0{\%}) had evidence of past or current hepatitis A infection. Of the 1,117 (86.5{\%}) men with unambiguous HBV test results, 442 (39.6{\%}) had serologic evidence of past/current infection, 103 (9.2{\%}) were immune due to hepatitis B vaccination, 572 (51.2{\%}) had no evidence of immunological exposure to HBV or vaccine. Of those with past/current HBV infection, 130 (29.4{\%}) were HIV positive. Age >35 years was independently associated with both HAV and HBV infection. University education was protective against both HAV and HBV infection. Increased alcohol consumption, number of lifetime male sexual partners ≥10, and prevalent HIV infection were also independently associated with HBV infection. The prevalence of past/current HAV and HBV infection was high in Bangkok men who have sex with men. Age-cohorts with a higher prevalence of hepatitis B vaccine induced immunity may be expected in the future. Hepatitis A and B vaccination is recommended.",
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AU - Chaikummao, Supaporn

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AU - Tongtoyai, Jaray

AU - Mock, Philip A.

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