Hepatic allograft abscess with hepatic arterial thrombosis

John M. Rabkin, Susan Orloff, Christopher Corless, Kent G. Benner, Ken D. Flora, Hugo R. Rosen, Frederick Keller, Robert Barton, Paul C. Lakin, Bryan Petersen, Richard R. Saxon, Ali J. Olyaei

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

BACKGROUND: Intrahepatic abscess (IA) is an uncommon complication after liver transplantation (OLTx) usually found in the setting of hepatic arterial thrombosis (HAT) often with associated biliary tree necrosis and/or stricture. Conventional treatment of IA in this setting has required retransplantation. METHODS: A retrospective review of 274 patients (287 OLTx) from September 1991 through September 1996 was performed. Median follow-up was 3.6 years. Diagnosis of HAT was confirmed by arteriography and IA was documented by computerized tomography. Percutaneous drainage of the abscess and stenting of biliary strictures, if present, was achieved using conventional interventional radiology techniques. RESULTS: The diagnosis of hepatic artery complication was made in 14 patients (5.1%), 2 of whom required retransplantation. Hepatic artery thrombosis associated with solitary IA was found in 3 patients (1%) who were transplanted in our center and in I additional patient followed up at our center but transplanted elsewhere. All 4 patients had complete resolution of IA using this approach. Three of the 4 patients are alive and well, with the fourth patient succumbing to recurrent hepatitis B infection resulting in allograft failure. CONCLUSIONS: Solitary hepatic allograft abscesses associated with HAT respond to percutaneous drainage and antibiotics, obviating the need for retransplantation in this setting.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalAmerican Journal of Surgery
Volume175
Issue number5
DOIs
StatePublished - 1998

Fingerprint

Liver Abscess
Allografts
Thrombosis
Abscess
Liver
Hepatic Artery
Drainage
Pathologic Constriction
Interventional Radiology
Biliary Tract
Hepatitis B
Liver Transplantation
Angiography
Necrosis
Tomography
Anti-Bacterial Agents
Infection

ASJC Scopus subject areas

  • Surgery

Cite this

Rabkin, J. M., Orloff, S., Corless, C., Benner, K. G., Flora, K. D., Rosen, H. R., ... Olyaei, A. J. (1998). Hepatic allograft abscess with hepatic arterial thrombosis. American Journal of Surgery, 175(5), 354-359. https://doi.org/10.1016/S0002-9610(98)00051-8

Hepatic allograft abscess with hepatic arterial thrombosis. / Rabkin, John M.; Orloff, Susan; Corless, Christopher; Benner, Kent G.; Flora, Ken D.; Rosen, Hugo R.; Keller, Frederick; Barton, Robert; Lakin, Paul C.; Petersen, Bryan; Saxon, Richard R.; Olyaei, Ali J.

In: American Journal of Surgery, Vol. 175, No. 5, 1998, p. 354-359.

Research output: Contribution to journalArticle

Rabkin, JM, Orloff, S, Corless, C, Benner, KG, Flora, KD, Rosen, HR, Keller, F, Barton, R, Lakin, PC, Petersen, B, Saxon, RR & Olyaei, AJ 1998, 'Hepatic allograft abscess with hepatic arterial thrombosis', American Journal of Surgery, vol. 175, no. 5, pp. 354-359. https://doi.org/10.1016/S0002-9610(98)00051-8
Rabkin, John M. ; Orloff, Susan ; Corless, Christopher ; Benner, Kent G. ; Flora, Ken D. ; Rosen, Hugo R. ; Keller, Frederick ; Barton, Robert ; Lakin, Paul C. ; Petersen, Bryan ; Saxon, Richard R. ; Olyaei, Ali J. / Hepatic allograft abscess with hepatic arterial thrombosis. In: American Journal of Surgery. 1998 ; Vol. 175, No. 5. pp. 354-359.
@article{89dc380c7b764e32b2ded5e1ae812f1f,
title = "Hepatic allograft abscess with hepatic arterial thrombosis",
abstract = "BACKGROUND: Intrahepatic abscess (IA) is an uncommon complication after liver transplantation (OLTx) usually found in the setting of hepatic arterial thrombosis (HAT) often with associated biliary tree necrosis and/or stricture. Conventional treatment of IA in this setting has required retransplantation. METHODS: A retrospective review of 274 patients (287 OLTx) from September 1991 through September 1996 was performed. Median follow-up was 3.6 years. Diagnosis of HAT was confirmed by arteriography and IA was documented by computerized tomography. Percutaneous drainage of the abscess and stenting of biliary strictures, if present, was achieved using conventional interventional radiology techniques. RESULTS: The diagnosis of hepatic artery complication was made in 14 patients (5.1{\%}), 2 of whom required retransplantation. Hepatic artery thrombosis associated with solitary IA was found in 3 patients (1{\%}) who were transplanted in our center and in I additional patient followed up at our center but transplanted elsewhere. All 4 patients had complete resolution of IA using this approach. Three of the 4 patients are alive and well, with the fourth patient succumbing to recurrent hepatitis B infection resulting in allograft failure. CONCLUSIONS: Solitary hepatic allograft abscesses associated with HAT respond to percutaneous drainage and antibiotics, obviating the need for retransplantation in this setting.",
author = "Rabkin, {John M.} and Susan Orloff and Christopher Corless and Benner, {Kent G.} and Flora, {Ken D.} and Rosen, {Hugo R.} and Frederick Keller and Robert Barton and Lakin, {Paul C.} and Bryan Petersen and Saxon, {Richard R.} and Olyaei, {Ali J.}",
year = "1998",
doi = "10.1016/S0002-9610(98)00051-8",
language = "English (US)",
volume = "175",
pages = "354--359",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Hepatic allograft abscess with hepatic arterial thrombosis

AU - Rabkin, John M.

AU - Orloff, Susan

AU - Corless, Christopher

AU - Benner, Kent G.

AU - Flora, Ken D.

AU - Rosen, Hugo R.

AU - Keller, Frederick

AU - Barton, Robert

AU - Lakin, Paul C.

AU - Petersen, Bryan

AU - Saxon, Richard R.

AU - Olyaei, Ali J.

PY - 1998

Y1 - 1998

N2 - BACKGROUND: Intrahepatic abscess (IA) is an uncommon complication after liver transplantation (OLTx) usually found in the setting of hepatic arterial thrombosis (HAT) often with associated biliary tree necrosis and/or stricture. Conventional treatment of IA in this setting has required retransplantation. METHODS: A retrospective review of 274 patients (287 OLTx) from September 1991 through September 1996 was performed. Median follow-up was 3.6 years. Diagnosis of HAT was confirmed by arteriography and IA was documented by computerized tomography. Percutaneous drainage of the abscess and stenting of biliary strictures, if present, was achieved using conventional interventional radiology techniques. RESULTS: The diagnosis of hepatic artery complication was made in 14 patients (5.1%), 2 of whom required retransplantation. Hepatic artery thrombosis associated with solitary IA was found in 3 patients (1%) who were transplanted in our center and in I additional patient followed up at our center but transplanted elsewhere. All 4 patients had complete resolution of IA using this approach. Three of the 4 patients are alive and well, with the fourth patient succumbing to recurrent hepatitis B infection resulting in allograft failure. CONCLUSIONS: Solitary hepatic allograft abscesses associated with HAT respond to percutaneous drainage and antibiotics, obviating the need for retransplantation in this setting.

AB - BACKGROUND: Intrahepatic abscess (IA) is an uncommon complication after liver transplantation (OLTx) usually found in the setting of hepatic arterial thrombosis (HAT) often with associated biliary tree necrosis and/or stricture. Conventional treatment of IA in this setting has required retransplantation. METHODS: A retrospective review of 274 patients (287 OLTx) from September 1991 through September 1996 was performed. Median follow-up was 3.6 years. Diagnosis of HAT was confirmed by arteriography and IA was documented by computerized tomography. Percutaneous drainage of the abscess and stenting of biliary strictures, if present, was achieved using conventional interventional radiology techniques. RESULTS: The diagnosis of hepatic artery complication was made in 14 patients (5.1%), 2 of whom required retransplantation. Hepatic artery thrombosis associated with solitary IA was found in 3 patients (1%) who were transplanted in our center and in I additional patient followed up at our center but transplanted elsewhere. All 4 patients had complete resolution of IA using this approach. Three of the 4 patients are alive and well, with the fourth patient succumbing to recurrent hepatitis B infection resulting in allograft failure. CONCLUSIONS: Solitary hepatic allograft abscesses associated with HAT respond to percutaneous drainage and antibiotics, obviating the need for retransplantation in this setting.

UR - http://www.scopus.com/inward/record.url?scp=0031946951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031946951&partnerID=8YFLogxK

U2 - 10.1016/S0002-9610(98)00051-8

DO - 10.1016/S0002-9610(98)00051-8

M3 - Article

C2 - 9600276

AN - SCOPUS:0031946951

VL - 175

SP - 354

EP - 359

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 5

ER -