Heparin-induced thrombocytopenia in neonates.

Julie Martchenke, Lynn Boshkov

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Heparin-induced thrombocytopenia (HIT), an immune-mediated response to heparin administration, has been recognized in adults for some time, but only recently recognized in neonates and children. HIT Type I is a mild, self-limiting condition. HIT type II is a severe immune reaction to heparin that leads to thrombocytopenia and often thromboembolic complications. The incidence of HIT Type II is 2-5 percent in adults on heparin products and may be as high in neonates and children. The mortality rate from HIT in adults is 7-30 percent and is unknown but potentially high in newborns as well. The cardinal sign of HIT is a drop in platelet count by 50 percent or platelet counts below 70,000-100,000/mm3. This drop usually occurs five to ten days after the first exposure to heparin. Treatment is immediate cessation of all heparin therapy and initiation of alternative anticoagulants, especially the direct thrombin inhibitors lepirudin and argatroban. This article reviews the literature on HIT and presents a case of neonatal HIT following heart surgery.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalNeonatal network : NN
Volume24
Issue number5
StatePublished - 2005

Fingerprint

Thrombocytopenia
Heparin
Newborn Infant
Platelet Count
Idiopathic Thrombocytopenic Purpura
Antithrombins
Complementary Therapies
Anticoagulants
Thoracic Surgery

Cite this

Martchenke, J., & Boshkov, L. (2005). Heparin-induced thrombocytopenia in neonates. Neonatal network : NN, 24(5), 33-37.

Heparin-induced thrombocytopenia in neonates. / Martchenke, Julie; Boshkov, Lynn.

In: Neonatal network : NN, Vol. 24, No. 5, 2005, p. 33-37.

Research output: Contribution to journalArticle

Martchenke, J & Boshkov, L 2005, 'Heparin-induced thrombocytopenia in neonates.', Neonatal network : NN, vol. 24, no. 5, pp. 33-37.
Martchenke J, Boshkov L. Heparin-induced thrombocytopenia in neonates. Neonatal network : NN. 2005;24(5):33-37.
Martchenke, Julie ; Boshkov, Lynn. / Heparin-induced thrombocytopenia in neonates. In: Neonatal network : NN. 2005 ; Vol. 24, No. 5. pp. 33-37.
@article{08951990be084dff9c044a5fee1f919e,
title = "Heparin-induced thrombocytopenia in neonates.",
abstract = "Heparin-induced thrombocytopenia (HIT), an immune-mediated response to heparin administration, has been recognized in adults for some time, but only recently recognized in neonates and children. HIT Type I is a mild, self-limiting condition. HIT type II is a severe immune reaction to heparin that leads to thrombocytopenia and often thromboembolic complications. The incidence of HIT Type II is 2-5 percent in adults on heparin products and may be as high in neonates and children. The mortality rate from HIT in adults is 7-30 percent and is unknown but potentially high in newborns as well. The cardinal sign of HIT is a drop in platelet count by 50 percent or platelet counts below 70,000-100,000/mm3. This drop usually occurs five to ten days after the first exposure to heparin. Treatment is immediate cessation of all heparin therapy and initiation of alternative anticoagulants, especially the direct thrombin inhibitors lepirudin and argatroban. This article reviews the literature on HIT and presents a case of neonatal HIT following heart surgery.",
author = "Julie Martchenke and Lynn Boshkov",
year = "2005",
language = "English (US)",
volume = "24",
pages = "33--37",
journal = "Neonatal network : NN",
issn = "0730-0832",
publisher = "Neonatal Network",
number = "5",

}

TY - JOUR

T1 - Heparin-induced thrombocytopenia in neonates.

AU - Martchenke, Julie

AU - Boshkov, Lynn

PY - 2005

Y1 - 2005

N2 - Heparin-induced thrombocytopenia (HIT), an immune-mediated response to heparin administration, has been recognized in adults for some time, but only recently recognized in neonates and children. HIT Type I is a mild, self-limiting condition. HIT type II is a severe immune reaction to heparin that leads to thrombocytopenia and often thromboembolic complications. The incidence of HIT Type II is 2-5 percent in adults on heparin products and may be as high in neonates and children. The mortality rate from HIT in adults is 7-30 percent and is unknown but potentially high in newborns as well. The cardinal sign of HIT is a drop in platelet count by 50 percent or platelet counts below 70,000-100,000/mm3. This drop usually occurs five to ten days after the first exposure to heparin. Treatment is immediate cessation of all heparin therapy and initiation of alternative anticoagulants, especially the direct thrombin inhibitors lepirudin and argatroban. This article reviews the literature on HIT and presents a case of neonatal HIT following heart surgery.

AB - Heparin-induced thrombocytopenia (HIT), an immune-mediated response to heparin administration, has been recognized in adults for some time, but only recently recognized in neonates and children. HIT Type I is a mild, self-limiting condition. HIT type II is a severe immune reaction to heparin that leads to thrombocytopenia and often thromboembolic complications. The incidence of HIT Type II is 2-5 percent in adults on heparin products and may be as high in neonates and children. The mortality rate from HIT in adults is 7-30 percent and is unknown but potentially high in newborns as well. The cardinal sign of HIT is a drop in platelet count by 50 percent or platelet counts below 70,000-100,000/mm3. This drop usually occurs five to ten days after the first exposure to heparin. Treatment is immediate cessation of all heparin therapy and initiation of alternative anticoagulants, especially the direct thrombin inhibitors lepirudin and argatroban. This article reviews the literature on HIT and presents a case of neonatal HIT following heart surgery.

UR - http://www.scopus.com/inward/record.url?scp=33644667114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644667114&partnerID=8YFLogxK

M3 - Article

VL - 24

SP - 33

EP - 37

JO - Neonatal network : NN

JF - Neonatal network : NN

SN - 0730-0832

IS - 5

ER -