Hemostatic efficacy of chitosan-based bandage for closure of percutaneous arterial access sites

An experimental study in heparinized sheep model

Pawanrat Kranokpiraksa, Dusan Pavcnik, Hideaki Kakizawa, Barry Uchida, Miran Jeromel, Frederick Keller, Josef Rosch

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. Most of the presently used percutaneous arterial closure devices (PACD) for hemostasis after interventional vascular procedures are effective, but carry risk of complications by deposition of a foreign body. A new promising externally applied PACD - chitosan-based HemCon Bandage (HCB) was explored in sheep. The HCB hemostatic efficacy and complications occurring with its use were compared to those with the standard manual compression (SMC).Material and methods. Both superficial femoral arteries (SFA) of 9 heparinized sheep were catheterized with an 8F sheath for 5 minutes. After the sheath withdrawal, hemostasis with the HCB was compared with hemostasis achieved with SMC in the contralateral SFA. Iliac angiograms performed by carotid artery approach determined the hemostasis time.Results. The HCB use shortened time to hemostasis with a mean time of 6.9 ± 3.9 minutes versus 10.8 ± 2.8 minutes for the SMC (P-value 0.019). Seven SFAs in the HCB group and only 1 SFA in the SMC group exhibited hemostasis in 5 minutes. All nine SFAs using the HCB showed femoral artery patency and demonstrated less hematoma (2/9) than in the SMC group (8/9). No complications developed in the HCB group, one SFA occlusion was seen in the SMC group.Conclusions. The externally applied HCB in heparinized sheep was safe and effective. It significantly shortened time to hemostasis at the SFA access sites following 8F sheath removal. Proper application of the HCB was necessary to shorten hemostasis and prevent hematoma formation. The HCB should be tested in a clinically controlled study to evaluate its efficacy in humans.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalRadiology and Oncology
Volume44
Issue number2
DOIs
StatePublished - Jun 1 2010

Fingerprint

Chitosan
Hemostatics
Bandages
Sheep
Hemostasis
Femoral Artery
Hematoma
Equipment and Supplies
Foreign Bodies
Carotid Arteries
Blood Vessels
Angiography

Keywords

  • Arterial catheterization
  • Chitosan-based pad
  • Closure devices
  • Hemostasis
  • Hemostatic pads

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Hemostatic efficacy of chitosan-based bandage for closure of percutaneous arterial access sites : An experimental study in heparinized sheep model. / Kranokpiraksa, Pawanrat; Pavcnik, Dusan; Kakizawa, Hideaki; Uchida, Barry; Jeromel, Miran; Keller, Frederick; Rosch, Josef.

In: Radiology and Oncology, Vol. 44, No. 2, 01.06.2010, p. 86-91.

Research output: Contribution to journalArticle

Kranokpiraksa, Pawanrat ; Pavcnik, Dusan ; Kakizawa, Hideaki ; Uchida, Barry ; Jeromel, Miran ; Keller, Frederick ; Rosch, Josef. / Hemostatic efficacy of chitosan-based bandage for closure of percutaneous arterial access sites : An experimental study in heparinized sheep model. In: Radiology and Oncology. 2010 ; Vol. 44, No. 2. pp. 86-91.
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N2 - Background. Most of the presently used percutaneous arterial closure devices (PACD) for hemostasis after interventional vascular procedures are effective, but carry risk of complications by deposition of a foreign body. A new promising externally applied PACD - chitosan-based HemCon Bandage (HCB) was explored in sheep. The HCB hemostatic efficacy and complications occurring with its use were compared to those with the standard manual compression (SMC).Material and methods. Both superficial femoral arteries (SFA) of 9 heparinized sheep were catheterized with an 8F sheath for 5 minutes. After the sheath withdrawal, hemostasis with the HCB was compared with hemostasis achieved with SMC in the contralateral SFA. Iliac angiograms performed by carotid artery approach determined the hemostasis time.Results. The HCB use shortened time to hemostasis with a mean time of 6.9 ± 3.9 minutes versus 10.8 ± 2.8 minutes for the SMC (P-value 0.019). Seven SFAs in the HCB group and only 1 SFA in the SMC group exhibited hemostasis in 5 minutes. All nine SFAs using the HCB showed femoral artery patency and demonstrated less hematoma (2/9) than in the SMC group (8/9). No complications developed in the HCB group, one SFA occlusion was seen in the SMC group.Conclusions. The externally applied HCB in heparinized sheep was safe and effective. It significantly shortened time to hemostasis at the SFA access sites following 8F sheath removal. Proper application of the HCB was necessary to shorten hemostasis and prevent hematoma formation. The HCB should be tested in a clinically controlled study to evaluate its efficacy in humans.

AB - Background. Most of the presently used percutaneous arterial closure devices (PACD) for hemostasis after interventional vascular procedures are effective, but carry risk of complications by deposition of a foreign body. A new promising externally applied PACD - chitosan-based HemCon Bandage (HCB) was explored in sheep. The HCB hemostatic efficacy and complications occurring with its use were compared to those with the standard manual compression (SMC).Material and methods. Both superficial femoral arteries (SFA) of 9 heparinized sheep were catheterized with an 8F sheath for 5 minutes. After the sheath withdrawal, hemostasis with the HCB was compared with hemostasis achieved with SMC in the contralateral SFA. Iliac angiograms performed by carotid artery approach determined the hemostasis time.Results. The HCB use shortened time to hemostasis with a mean time of 6.9 ± 3.9 minutes versus 10.8 ± 2.8 minutes for the SMC (P-value 0.019). Seven SFAs in the HCB group and only 1 SFA in the SMC group exhibited hemostasis in 5 minutes. All nine SFAs using the HCB showed femoral artery patency and demonstrated less hematoma (2/9) than in the SMC group (8/9). No complications developed in the HCB group, one SFA occlusion was seen in the SMC group.Conclusions. The externally applied HCB in heparinized sheep was safe and effective. It significantly shortened time to hemostasis at the SFA access sites following 8F sheath removal. Proper application of the HCB was necessary to shorten hemostasis and prevent hematoma formation. The HCB should be tested in a clinically controlled study to evaluate its efficacy in humans.

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