Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth

Veronica H. Flood, Faith C. Galderisi, Stefanie R. Lowas, Angela Kendrick, Lynn Boshkov

Research output: Contribution to journalArticle

21 Scopus citations


Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.

Original languageEnglish (US)
Pages (from-to)1075-1077
Number of pages3
JournalPediatric Blood and Cancer
Issue number5
Publication statusPublished - May 2008



  • Bleeding disorders
  • Esp. in newborns
  • Intracranial hemorrhage
  • Vitamin K

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Flood, V. H., Galderisi, F. C., Lowas, S. R., Kendrick, A., & Boshkov, L. (2008). Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth. Pediatric Blood and Cancer, 50(5), 1075-1077. https://doi.org/10.1002/pbc.21383