Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth

Veronica H. Flood, Faith C. Galderisi, Stefanie R. Lowas, Angela Kendrick, Lynn Boshkov

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.

Original languageEnglish (US)
Pages (from-to)1075-1077
Number of pages3
JournalPediatric Blood and Cancer
Volume50
Issue number5
DOIs
StatePublished - May 2008

Fingerprint

Vitamin K Deficiency Bleeding
Vitamin K
Parturition
Intracranial Hemorrhages
Diarrhea
Newborn Infant
Hemorrhage
Morbidity

Keywords

  • Bleeding disorders
  • Esp. in newborns
  • Intracranial hemorrhage
  • Vitamin K

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Flood, V. H., Galderisi, F. C., Lowas, S. R., Kendrick, A., & Boshkov, L. (2008). Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth. Pediatric Blood and Cancer, 50(5), 1075-1077. https://doi.org/10.1002/pbc.21383

Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth. / Flood, Veronica H.; Galderisi, Faith C.; Lowas, Stefanie R.; Kendrick, Angela; Boshkov, Lynn.

In: Pediatric Blood and Cancer, Vol. 50, No. 5, 05.2008, p. 1075-1077.

Research output: Contribution to journalArticle

Flood, VH, Galderisi, FC, Lowas, SR, Kendrick, A & Boshkov, L 2008, 'Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth', Pediatric Blood and Cancer, vol. 50, no. 5, pp. 1075-1077. https://doi.org/10.1002/pbc.21383
Flood, Veronica H. ; Galderisi, Faith C. ; Lowas, Stefanie R. ; Kendrick, Angela ; Boshkov, Lynn. / Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth. In: Pediatric Blood and Cancer. 2008 ; Vol. 50, No. 5. pp. 1075-1077.
@article{8c90ab48ac2844f68ed49c86741b8ac4,
title = "Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth",
abstract = "Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.",
keywords = "Bleeding disorders, Esp. in newborns, Intracranial hemorrhage, Vitamin K",
author = "Flood, {Veronica H.} and Galderisi, {Faith C.} and Lowas, {Stefanie R.} and Angela Kendrick and Lynn Boshkov",
year = "2008",
month = "5",
doi = "10.1002/pbc.21383",
language = "English (US)",
volume = "50",
pages = "1075--1077",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth

AU - Flood, Veronica H.

AU - Galderisi, Faith C.

AU - Lowas, Stefanie R.

AU - Kendrick, Angela

AU - Boshkov, Lynn

PY - 2008/5

Y1 - 2008/5

N2 - Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.

AB - Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.

KW - Bleeding disorders

KW - Esp. in newborns

KW - Intracranial hemorrhage

KW - Vitamin K

UR - http://www.scopus.com/inward/record.url?scp=41849099695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41849099695&partnerID=8YFLogxK

U2 - 10.1002/pbc.21383

DO - 10.1002/pbc.21383

M3 - Article

C2 - 17957759

AN - SCOPUS:41849099695

VL - 50

SP - 1075

EP - 1077

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 5

ER -