Hemodynamically significant PDA: An echocardiographic and clinical assessment of incidence, natural history, and outcome in very low birth weight infants maintained in negative fluid balance

Mark Reller, John M. Lorenz, Uma R. Kotagal, Richard A. Meyer, Samuel Kaplan

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Fifty very low birth weight (VLBW) infants (750-1500 g, 27-33 weeks gestational age) were assigned at random to one of two groups of negative fluid balance and underwent prospective clinical and echocardiographic examinations during the first month of life. The purpose was to determine: (a) the effect of fluid restriction on the incidence of ductal shunting, (b) the reliability of the physical examination in diagnosing significant ductal shunting, and (c) the relationship between significant ductal shunting and outcome in such infants. None of the infants had manipulations to close the ductus during the first week of life. Using routine structural and functional echocardiographic indices as criteria for the diagnosis of hemodynamically significant ductal shunting (hsPDA), we found that the two fluid-balance groups (8%-10% weight loss vs 13%-15% weight loss) did not significantly differ in incidence of hsPDA, duration of ventilation, or development of BPD. These two groups were then combined for further analysis: 32 (64%) of 50 VLBW infants had hsPDA during the first week of life. The group of infants with hsPDA did not differ significantly from that without hsPDA in birth weight or gestational age, but had a significantly lower Apgar score (P

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalPediatric Cardiology
Volume6
Issue number1
DOIs
StatePublished - Mar 1985
Externally publishedYes

Fingerprint

Very Low Birth Weight Infant
Water-Electrolyte Balance
Natural History
Gestational Age
Weight Loss
Incidence
Apgar Score
Birth Weight
Physical Examination
Ventilation

Keywords

  • Echocardiography
  • Fluid balance
  • PDA
  • VLBW infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Hemodynamically significant PDA : An echocardiographic and clinical assessment of incidence, natural history, and outcome in very low birth weight infants maintained in negative fluid balance. / Reller, Mark; Lorenz, John M.; Kotagal, Uma R.; Meyer, Richard A.; Kaplan, Samuel.

In: Pediatric Cardiology, Vol. 6, No. 1, 03.1985, p. 17-23.

Research output: Contribution to journalArticle

@article{0f607fc80d2d4ea9a31001403719f4d7,
title = "Hemodynamically significant PDA: An echocardiographic and clinical assessment of incidence, natural history, and outcome in very low birth weight infants maintained in negative fluid balance",
abstract = "Fifty very low birth weight (VLBW) infants (750-1500 g, 27-33 weeks gestational age) were assigned at random to one of two groups of negative fluid balance and underwent prospective clinical and echocardiographic examinations during the first month of life. The purpose was to determine: (a) the effect of fluid restriction on the incidence of ductal shunting, (b) the reliability of the physical examination in diagnosing significant ductal shunting, and (c) the relationship between significant ductal shunting and outcome in such infants. None of the infants had manipulations to close the ductus during the first week of life. Using routine structural and functional echocardiographic indices as criteria for the diagnosis of hemodynamically significant ductal shunting (hsPDA), we found that the two fluid-balance groups (8{\%}-10{\%} weight loss vs 13{\%}-15{\%} weight loss) did not significantly differ in incidence of hsPDA, duration of ventilation, or development of BPD. These two groups were then combined for further analysis: 32 (64{\%}) of 50 VLBW infants had hsPDA during the first week of life. The group of infants with hsPDA did not differ significantly from that without hsPDA in birth weight or gestational age, but had a significantly lower Apgar score (P",
keywords = "Echocardiography, Fluid balance, PDA, VLBW infants",
author = "Mark Reller and Lorenz, {John M.} and Kotagal, {Uma R.} and Meyer, {Richard A.} and Samuel Kaplan",
year = "1985",
month = "3",
doi = "10.1007/BF02265403",
language = "English (US)",
volume = "6",
pages = "17--23",
journal = "Pediatric Cardiology",
issn = "0172-0643",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Hemodynamically significant PDA

T2 - An echocardiographic and clinical assessment of incidence, natural history, and outcome in very low birth weight infants maintained in negative fluid balance

AU - Reller, Mark

AU - Lorenz, John M.

AU - Kotagal, Uma R.

AU - Meyer, Richard A.

AU - Kaplan, Samuel

PY - 1985/3

Y1 - 1985/3

N2 - Fifty very low birth weight (VLBW) infants (750-1500 g, 27-33 weeks gestational age) were assigned at random to one of two groups of negative fluid balance and underwent prospective clinical and echocardiographic examinations during the first month of life. The purpose was to determine: (a) the effect of fluid restriction on the incidence of ductal shunting, (b) the reliability of the physical examination in diagnosing significant ductal shunting, and (c) the relationship between significant ductal shunting and outcome in such infants. None of the infants had manipulations to close the ductus during the first week of life. Using routine structural and functional echocardiographic indices as criteria for the diagnosis of hemodynamically significant ductal shunting (hsPDA), we found that the two fluid-balance groups (8%-10% weight loss vs 13%-15% weight loss) did not significantly differ in incidence of hsPDA, duration of ventilation, or development of BPD. These two groups were then combined for further analysis: 32 (64%) of 50 VLBW infants had hsPDA during the first week of life. The group of infants with hsPDA did not differ significantly from that without hsPDA in birth weight or gestational age, but had a significantly lower Apgar score (P

AB - Fifty very low birth weight (VLBW) infants (750-1500 g, 27-33 weeks gestational age) were assigned at random to one of two groups of negative fluid balance and underwent prospective clinical and echocardiographic examinations during the first month of life. The purpose was to determine: (a) the effect of fluid restriction on the incidence of ductal shunting, (b) the reliability of the physical examination in diagnosing significant ductal shunting, and (c) the relationship between significant ductal shunting and outcome in such infants. None of the infants had manipulations to close the ductus during the first week of life. Using routine structural and functional echocardiographic indices as criteria for the diagnosis of hemodynamically significant ductal shunting (hsPDA), we found that the two fluid-balance groups (8%-10% weight loss vs 13%-15% weight loss) did not significantly differ in incidence of hsPDA, duration of ventilation, or development of BPD. These two groups were then combined for further analysis: 32 (64%) of 50 VLBW infants had hsPDA during the first week of life. The group of infants with hsPDA did not differ significantly from that without hsPDA in birth weight or gestational age, but had a significantly lower Apgar score (P

KW - Echocardiography

KW - Fluid balance

KW - PDA

KW - VLBW infants

UR - http://www.scopus.com/inward/record.url?scp=0022254639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022254639&partnerID=8YFLogxK

U2 - 10.1007/BF02265403

DO - 10.1007/BF02265403

M3 - Article

C2 - 4011463

AN - SCOPUS:0022254639

VL - 6

SP - 17

EP - 23

JO - Pediatric Cardiology

JF - Pediatric Cardiology

SN - 0172-0643

IS - 1

ER -