Hemodynamic effects of lipids in humans

Milos P. Stojiljkovic, Da Zhang, Heno F. Lopes, Christine Lee, Theodore L. Goodfriend, Brent M. Egan

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Evidence suggests lipid abnormalities may contribute to elevated blood pressure, increased vascular resistance, and reduced arterial compliance among insulin-resistant subjects. In a study of 11 normal volunteers undergoing 4-h-long infusions of Intralipid and heparin to raise plasma nonesterified fatty acids (NEFAs), we observed increases of blood pressure. In contrast, blood pressure did not change in these same volunteers during a 4-h infusion of saline and heparin. To better characterize the hemodynamic responses to Intralipid and heparin, another group of 21 individuals, including both lean and obese volunteers, was studied after 3 wk on a controlled diet with 180 mmol sodium/day. Two and four hours after starting the infusions, plasma NEFAs increased by 134 and 111% in those receiving Intralipid and heparin, P <0.01, whereas plasma NEFAs did not change in the first group of normal volunteers who received saline and heparin. The hemodynamic changes in lean and obese subjects in the second study were similar, and the results were combined. The infusion of Intralipid and heparin induced a significant increase in systolic (13.5 ± 2.1 mmHg) and diastolic (8.0 ± 1.5 mmHg) blood pressure as well as heart rate (9.4 ± 1.4 beats/min). Small and large artery compliance decreased, and systemic vascular resistance rose. These data raise the possibility that lipid abnormalities associated with insulin resistance contribute to the elevated blood pressure and heart rate as well as the reduced vascular compliance observed in subjects with the cardiovascular risk factor cluster.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume280
Issue number6 49-6
StatePublished - 2001
Externally publishedYes

Fingerprint

Heparin
Hemodynamics
Lipids
Blood Pressure
Nonesterified Fatty Acids
Compliance
Vascular Resistance
Volunteers
Healthy Volunteers
Heart Rate
Blood Vessels
Insulin Resistance
Arteries
Sodium
Insulin
Diet
phospholipid emulsion soybean oil

Keywords

  • Blood pressure
  • Hypertension
  • Nonesterified fatty acids

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Stojiljkovic, M. P., Zhang, D., Lopes, H. F., Lee, C., Goodfriend, T. L., & Egan, B. M. (2001). Hemodynamic effects of lipids in humans. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 280(6 49-6).

Hemodynamic effects of lipids in humans. / Stojiljkovic, Milos P.; Zhang, Da; Lopes, Heno F.; Lee, Christine; Goodfriend, Theodore L.; Egan, Brent M.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 280, No. 6 49-6, 2001.

Research output: Contribution to journalArticle

Stojiljkovic, MP, Zhang, D, Lopes, HF, Lee, C, Goodfriend, TL & Egan, BM 2001, 'Hemodynamic effects of lipids in humans', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 280, no. 6 49-6.
Stojiljkovic MP, Zhang D, Lopes HF, Lee C, Goodfriend TL, Egan BM. Hemodynamic effects of lipids in humans. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2001;280(6 49-6).
Stojiljkovic, Milos P. ; Zhang, Da ; Lopes, Heno F. ; Lee, Christine ; Goodfriend, Theodore L. ; Egan, Brent M. / Hemodynamic effects of lipids in humans. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2001 ; Vol. 280, No. 6 49-6.
@article{f9b972f9b0ae4a39a5f4ec02a93d27e0,
title = "Hemodynamic effects of lipids in humans",
abstract = "Evidence suggests lipid abnormalities may contribute to elevated blood pressure, increased vascular resistance, and reduced arterial compliance among insulin-resistant subjects. In a study of 11 normal volunteers undergoing 4-h-long infusions of Intralipid and heparin to raise plasma nonesterified fatty acids (NEFAs), we observed increases of blood pressure. In contrast, blood pressure did not change in these same volunteers during a 4-h infusion of saline and heparin. To better characterize the hemodynamic responses to Intralipid and heparin, another group of 21 individuals, including both lean and obese volunteers, was studied after 3 wk on a controlled diet with 180 mmol sodium/day. Two and four hours after starting the infusions, plasma NEFAs increased by 134 and 111{\%} in those receiving Intralipid and heparin, P <0.01, whereas plasma NEFAs did not change in the first group of normal volunteers who received saline and heparin. The hemodynamic changes in lean and obese subjects in the second study were similar, and the results were combined. The infusion of Intralipid and heparin induced a significant increase in systolic (13.5 ± 2.1 mmHg) and diastolic (8.0 ± 1.5 mmHg) blood pressure as well as heart rate (9.4 ± 1.4 beats/min). Small and large artery compliance decreased, and systemic vascular resistance rose. These data raise the possibility that lipid abnormalities associated with insulin resistance contribute to the elevated blood pressure and heart rate as well as the reduced vascular compliance observed in subjects with the cardiovascular risk factor cluster.",
keywords = "Blood pressure, Hypertension, Nonesterified fatty acids",
author = "Stojiljkovic, {Milos P.} and Da Zhang and Lopes, {Heno F.} and Christine Lee and Goodfriend, {Theodore L.} and Egan, {Brent M.}",
year = "2001",
language = "English (US)",
volume = "280",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "6 49-6",

}

TY - JOUR

T1 - Hemodynamic effects of lipids in humans

AU - Stojiljkovic, Milos P.

AU - Zhang, Da

AU - Lopes, Heno F.

AU - Lee, Christine

AU - Goodfriend, Theodore L.

AU - Egan, Brent M.

PY - 2001

Y1 - 2001

N2 - Evidence suggests lipid abnormalities may contribute to elevated blood pressure, increased vascular resistance, and reduced arterial compliance among insulin-resistant subjects. In a study of 11 normal volunteers undergoing 4-h-long infusions of Intralipid and heparin to raise plasma nonesterified fatty acids (NEFAs), we observed increases of blood pressure. In contrast, blood pressure did not change in these same volunteers during a 4-h infusion of saline and heparin. To better characterize the hemodynamic responses to Intralipid and heparin, another group of 21 individuals, including both lean and obese volunteers, was studied after 3 wk on a controlled diet with 180 mmol sodium/day. Two and four hours after starting the infusions, plasma NEFAs increased by 134 and 111% in those receiving Intralipid and heparin, P <0.01, whereas plasma NEFAs did not change in the first group of normal volunteers who received saline and heparin. The hemodynamic changes in lean and obese subjects in the second study were similar, and the results were combined. The infusion of Intralipid and heparin induced a significant increase in systolic (13.5 ± 2.1 mmHg) and diastolic (8.0 ± 1.5 mmHg) blood pressure as well as heart rate (9.4 ± 1.4 beats/min). Small and large artery compliance decreased, and systemic vascular resistance rose. These data raise the possibility that lipid abnormalities associated with insulin resistance contribute to the elevated blood pressure and heart rate as well as the reduced vascular compliance observed in subjects with the cardiovascular risk factor cluster.

AB - Evidence suggests lipid abnormalities may contribute to elevated blood pressure, increased vascular resistance, and reduced arterial compliance among insulin-resistant subjects. In a study of 11 normal volunteers undergoing 4-h-long infusions of Intralipid and heparin to raise plasma nonesterified fatty acids (NEFAs), we observed increases of blood pressure. In contrast, blood pressure did not change in these same volunteers during a 4-h infusion of saline and heparin. To better characterize the hemodynamic responses to Intralipid and heparin, another group of 21 individuals, including both lean and obese volunteers, was studied after 3 wk on a controlled diet with 180 mmol sodium/day. Two and four hours after starting the infusions, plasma NEFAs increased by 134 and 111% in those receiving Intralipid and heparin, P <0.01, whereas plasma NEFAs did not change in the first group of normal volunteers who received saline and heparin. The hemodynamic changes in lean and obese subjects in the second study were similar, and the results were combined. The infusion of Intralipid and heparin induced a significant increase in systolic (13.5 ± 2.1 mmHg) and diastolic (8.0 ± 1.5 mmHg) blood pressure as well as heart rate (9.4 ± 1.4 beats/min). Small and large artery compliance decreased, and systemic vascular resistance rose. These data raise the possibility that lipid abnormalities associated with insulin resistance contribute to the elevated blood pressure and heart rate as well as the reduced vascular compliance observed in subjects with the cardiovascular risk factor cluster.

KW - Blood pressure

KW - Hypertension

KW - Nonesterified fatty acids

UR - http://www.scopus.com/inward/record.url?scp=0034977240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034977240&partnerID=8YFLogxK

M3 - Article

VL - 280

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 6 49-6

ER -