Hemodynamic effects of corticotropin releasing hormone in the anesthetized cynomolgus monkey

Robert Udelsman, William T. Gallucci, John Bacher, D. Lynn Loriaux, George P. Chrousos

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Right atrial bolus administration of rat/human corticotropin releasing hormone (r/hCRH) at a dose of 90 μg/kg to anesthetized cynomolgus monkeys caused a dramatic and prolonged fall in both the peripheral vascular resistance (48% reduction) and mean systemic blood pressure (36% reduction). An associated tachycardia could be blocked with prior propranolol administration and thus was probably reflexic. A mean 43 and 37% increase in the flow of the superior mesenteric and common iliac arteries, respectively, was demonstrated with electromagnetic flow probes. These changes were associated with a concomitant 38 and 40% dimunution in the respective vascular resistance. Similar blood flow changes were noted in the carotid artery, however, these were of a much shorter duration. None of these changes occurred in placebo-treated animals. Plasma adrenocorticotropic hormone and cortisol concentrations were elevated basally and throughout the procedure and were similar in the experimental and control groups, suggesting maximal activity of the hypothalamic-pituitary-adrenal axis. Plasma renin activity, however, gradually increased in the r/hCRH-treated animals, probably as a result of the systemic hypotension. We speculate that CRH or a CRH-like substance may function as a paracrine hormone modulating local blood vessel tone and may be important in directing blood flow during stress and injury. The vasoactive properties of exogenous r/hCRH may be of clinical use in man.

Original languageEnglish (US)
Pages (from-to)465-471
Number of pages7
JournalPeptides
Volume7
Issue number3
DOIs
StatePublished - Jan 1 1986

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Keywords

  • Corticotropin releasing hormone
  • Cynomolgus monkey
  • Vasodilator

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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