TY - JOUR
T1 - Hematopoietic progenitor colony formation in the immunopathogenesis of the autoimmune disorder in MRL/MpJ-lpr mice.
AU - Toporkova, Ludmila B.
AU - Dubrovskaya, Viktoriya V.
AU - Sakhno, Ludmila V.
AU - Tikhonova, Marina A.
AU - Chernykh, Elena R.
AU - Buneva, Valentina N.
AU - Nevinsky, Georgy A.
AU - Kozlov, Vladimir A.
AU - Orlovskaya, Irina A.
PY - 2002/10
Y1 - 2002/10
N2 - Lymphocyte proliferation and apoptosis at different stages of the development of the autoimmune disorder in MRL/MpJ-lpr mice was studied. Hematopoietic progenitor colony formation during the course of the disease was characterized. A detectable difference at the level of lymphocyte proliferation, apoptosis, and the relative amount of BFU-E, CFU-GM and CFU-GEMM cell colonies was revealed between healthy young mice and animals spontaneously developing pronounced symptoms of the autoimmune disorder. The quantity of BFU-E and CFU-GEMM colonies was remarkably increases in aged MRL/MpJ-lpr mice even before clinical manifestation of the disease (proteinuria). An elevated number of CFU-GEMM was accompanied by a striking increase in their size. The study of hematopoietic disturbances in autoimmune MRL/MpJ-lpr mice may be very useful for understanding the mechanism of the autoimmune disease development and searching for new strategies of the correction of the autoimmune disorder.
AB - Lymphocyte proliferation and apoptosis at different stages of the development of the autoimmune disorder in MRL/MpJ-lpr mice was studied. Hematopoietic progenitor colony formation during the course of the disease was characterized. A detectable difference at the level of lymphocyte proliferation, apoptosis, and the relative amount of BFU-E, CFU-GM and CFU-GEMM cell colonies was revealed between healthy young mice and animals spontaneously developing pronounced symptoms of the autoimmune disorder. The quantity of BFU-E and CFU-GEMM colonies was remarkably increases in aged MRL/MpJ-lpr mice even before clinical manifestation of the disease (proteinuria). An elevated number of CFU-GEMM was accompanied by a striking increase in their size. The study of hematopoietic disturbances in autoimmune MRL/MpJ-lpr mice may be very useful for understanding the mechanism of the autoimmune disease development and searching for new strategies of the correction of the autoimmune disorder.
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M3 - Article
C2 - 12674934
AN - SCOPUS:0036824345
SN - 1028-7221
VL - 7
SP - 245
EP - 250
JO - Russian journal of immunology : RJI : official journal of Russian Society of Immunology
JF - Russian journal of immunology : RJI : official journal of Russian Society of Immunology
IS - 3
ER -