Hematopoietic progenitor colony formation in the immunopathogenesis of the autoimmune disorder in MRL/MpJ-lpr mice.

Ludmila B. Toporkova, Viktoriya V. Dubrovskaya, Ludmila V. Sakhno, Marina A. Tikhonova, Elena R. Chernykh, Valentina N. Buneva, Georgy A. Nevinsky, Vladimir A. Kozlov, Irina A. Orlovskaya

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Lymphocyte proliferation and apoptosis at different stages of the development of the autoimmune disorder in MRL/MpJ-lpr mice was studied. Hematopoietic progenitor colony formation during the course of the disease was characterized. A detectable difference at the level of lymphocyte proliferation, apoptosis, and the relative amount of BFU-E, CFU-GM and CFU-GEMM cell colonies was revealed between healthy young mice and animals spontaneously developing pronounced symptoms of the autoimmune disorder. The quantity of BFU-E and CFU-GEMM colonies was remarkably increases in aged MRL/MpJ-lpr mice even before clinical manifestation of the disease (proteinuria). An elevated number of CFU-GEMM was accompanied by a striking increase in their size. The study of hematopoietic disturbances in autoimmune MRL/MpJ-lpr mice may be very useful for understanding the mechanism of the autoimmune disease development and searching for new strategies of the correction of the autoimmune disorder.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalRussian journal of immunology : RJI : official journal of Russian Society of Immunology
Volume7
Issue number3
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Immunology

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