Hematologic abnormalities in patients with endocrine and metabolic disorders

A wide variety of endocrine disorders can be associated with hematologic dysfunction. Usually the hematologic manifestations of endocrine disease are mild to moderate and self-limited. Correction of the endocrinopathy should result in clearing of the hematologic disturbance. Whereas it is prudent to recognize the impact of endocrinology on red cell, leukocyte, platelet, and coagulation physiology, serious hematologic disorders are usually not solely the result of endocrinopathies but are instead associated or coincident abnormalities. There are some situations (e.g., the coagulopathies associated with Cushing's syndrome, oral contraceptive use, or hypothyroidism) in which an appreciation of the attendent hematologic abnormalities may prompt preventative actions.