Abstract
The hematocrit dependence of flow signal (split-spectrum amplitude decorrelation angiography-SSADA decorrelation value) was investigated in this paper. Based on the normalized field temporal correlation function and concentration dependent particle scattering properties, the relationship between hematocrit and flow signal was analytically derived. Experimental verification of the relationship was performed with custom-designed microfluidic chips and human blood with 45%, 40% and 32% hematocrit. It was found that, in large flow channels and blood vessels, the normal hematocrit is near the decorrelation saturation point and therefore a change in hematocrit has little effect on the SSADA decorrelation value (flow signal). However, in narrow channels in the capillary size range, the effective hematocrit (adjusted for the overlap between OCT beam and channel) is in the range of 6.7-9.5% and therefore variation in hematocrit does significantly affect the flow signal.
| Original language | English (US) |
|---|---|
| Article number | #276240 |
| Pages (from-to) | 776-789 |
| Number of pages | 14 |
| Journal | Biomedical Optics Express |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2017 |
Fingerprint
Keywords
- Medical and biological imaging
- Ophthalmic optics and devices
- Optical coherence tomography
ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics
Cite this
Hematocrit dependence of flow signal in optical coherence tomography angiography. / Yang, Jianlong; Su, Johnny; Wang, Jie; Men, Silu; Yali, Jia; Huang, David; Liu, Gangjun.
In: Biomedical Optics Express, Vol. 8, No. 2, #276240, 01.02.2017, p. 776-789.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hematocrit dependence of flow signal in optical coherence tomography angiography
AU - Yang, Jianlong
AU - Su, Johnny
AU - Wang, Jie
AU - Men, Silu
AU - Yali, Jia
AU - Huang, David
AU - Liu, Gangjun
PY - 2017/2/1
Y1 - 2017/2/1
N2 - The hematocrit dependence of flow signal (split-spectrum amplitude decorrelation angiography-SSADA decorrelation value) was investigated in this paper. Based on the normalized field temporal correlation function and concentration dependent particle scattering properties, the relationship between hematocrit and flow signal was analytically derived. Experimental verification of the relationship was performed with custom-designed microfluidic chips and human blood with 45%, 40% and 32% hematocrit. It was found that, in large flow channels and blood vessels, the normal hematocrit is near the decorrelation saturation point and therefore a change in hematocrit has little effect on the SSADA decorrelation value (flow signal). However, in narrow channels in the capillary size range, the effective hematocrit (adjusted for the overlap between OCT beam and channel) is in the range of 6.7-9.5% and therefore variation in hematocrit does significantly affect the flow signal.
AB - The hematocrit dependence of flow signal (split-spectrum amplitude decorrelation angiography-SSADA decorrelation value) was investigated in this paper. Based on the normalized field temporal correlation function and concentration dependent particle scattering properties, the relationship between hematocrit and flow signal was analytically derived. Experimental verification of the relationship was performed with custom-designed microfluidic chips and human blood with 45%, 40% and 32% hematocrit. It was found that, in large flow channels and blood vessels, the normal hematocrit is near the decorrelation saturation point and therefore a change in hematocrit has little effect on the SSADA decorrelation value (flow signal). However, in narrow channels in the capillary size range, the effective hematocrit (adjusted for the overlap between OCT beam and channel) is in the range of 6.7-9.5% and therefore variation in hematocrit does significantly affect the flow signal.
KW - Medical and biological imaging
KW - Ophthalmic optics and devices
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85011579661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011579661&partnerID=8YFLogxK
U2 - 10.1364/BOE.8.000776
DO - 10.1364/BOE.8.000776
M3 - Article
AN - SCOPUS:85011579661
VL - 8
SP - 776
EP - 789
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 2
M1 - #276240
ER -