Heart rate increases in patients with growth hormone receptor deficiency treated with insulin-like growth factor I.

O. Vasconez, V. Martinez, A. L. Martinez, F. Hidalgo, F. B. Diamond, A. L. Rosenbloom, Ronald (Ron) Rosenfeld, J. Guevara-Aguirre

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22 Citations (Scopus)

Abstract

Cardiac function was measured in 16 prepubertal Ecuadorean patients with growth hormone receptor deficiency given insulin-like growth factor I (IGF-I) during part of a clinical trial. The IGF-I was given subcutaneously twice daily at a dose of 40 micrograms/kg on days 1 and 2, 80 micrograms/kg on days 3 and 4, and 120 micrograms/kg thereafter. Heart rate was determined at baseline (pretreatment) and on days 1-7 by repeated palpation of the radial artery and at baseline and on days 2, 4 and 7 by continuous portable Holter monitoring. Heart rate measured by both methods rose progressively with increasing doses of IGF-I. The mean palpated pulse exceeded baseline on each treatment day and was significantly higher on day 5 than day 4 and significantly higher on day 3 than day 2. The mean Holter heart rate was significantly higher on day 4 than on day 2 and significantly higher on day 2 than at baseline. Non-significant glucose and electrolyte changes did not appear to be associated with the cardiac events.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalActa paediatrica (Oslo, Norway : 1992). Supplement
Volume399
StatePublished - Apr 1994
Externally publishedYes

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Laron Syndrome
Insulin-Like Growth Factor I
Heart Rate
Ambulatory Electrocardiography
Radial Artery
Palpation
Electrolytes
Pulse
Clinical Trials
Glucose
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vasconez, O., Martinez, V., Martinez, A. L., Hidalgo, F., Diamond, F. B., Rosenbloom, A. L., ... Guevara-Aguirre, J. (1994). Heart rate increases in patients with growth hormone receptor deficiency treated with insulin-like growth factor I. Acta paediatrica (Oslo, Norway : 1992). Supplement, 399, 137-139.

Heart rate increases in patients with growth hormone receptor deficiency treated with insulin-like growth factor I. / Vasconez, O.; Martinez, V.; Martinez, A. L.; Hidalgo, F.; Diamond, F. B.; Rosenbloom, A. L.; Rosenfeld, Ronald (Ron); Guevara-Aguirre, J.

In: Acta paediatrica (Oslo, Norway : 1992). Supplement, Vol. 399, 04.1994, p. 137-139.

Research output: Contribution to journalArticle

Vasconez, O, Martinez, V, Martinez, AL, Hidalgo, F, Diamond, FB, Rosenbloom, AL, Rosenfeld, RR & Guevara-Aguirre, J 1994, 'Heart rate increases in patients with growth hormone receptor deficiency treated with insulin-like growth factor I.', Acta paediatrica (Oslo, Norway : 1992). Supplement, vol. 399, pp. 137-139.
Vasconez, O. ; Martinez, V. ; Martinez, A. L. ; Hidalgo, F. ; Diamond, F. B. ; Rosenbloom, A. L. ; Rosenfeld, Ronald (Ron) ; Guevara-Aguirre, J. / Heart rate increases in patients with growth hormone receptor deficiency treated with insulin-like growth factor I. In: Acta paediatrica (Oslo, Norway : 1992). Supplement. 1994 ; Vol. 399. pp. 137-139.
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