TY - JOUR
T1 - Hearing, mobility, and pain predict mortality
T2 - A longitudinal population-based study
AU - Feeny, David
AU - Huguet, Nathalie
AU - McFarland, Bentson H.
AU - Kaplan, Mark S.
AU - Orpana, Heather
AU - Eckstrom, Elizabeth
N1 - Funding Information:
Funding: This work was supported by grants to Mark S. Kaplan from the National Institute on Aging at the National Institutes of Health (“Longitudinal Analysis of Health-Related Quality of Life in an Aging Population,” R21 AG027129-01 ), the Retirement Research Foundation, the Canadian Studies Grant Program of the Canadian Embassy in Washington DC, and to David Feeny from the National Institute of Diabetes and Kidney Diseases at the National Institutes of Health (“Predictors of Weight and Quality of Life: A 12-Year National Longitudinal Study,” R21 1R21DK080277-01A1 ). None of these agencies have reviewed or approved the manuscript.
PY - 2012/7
Y1 - 2012/7
N2 - Objective: Measures of health-related quality of life (HRQL), including the Health Utilities Index Mark 3 (HUI3) are predictive of mortality. HUI3 includes eight attributes, vision, hearing, speech, ambulation, dexterity, cognition, emotion, and pain and discomfort, with five or six levels per attribute that vary from no to severe disability. This study examined associations between individual HUI3 attributes and mortality. Study Design and Setting: Baseline data and 12 years of follow-up data from a closed longitudinal cohort study, the 1994/95 Canadian National Population Health Survey, consisting of 12,375 women and men aged 18 and older. A priori hypotheses were that ambulation, cognition, emotion, and pain would predict mortality. Cox proportional hazards regression models were applied controlling for standard determinants of health and risk factors. Results: Single-attribute utility scores for ambulation (hazard ratio [HR] = 0.10; 0.04-0.22), hearing (HR = 0.18; 0.06-0.57), and pain (HR = 0.53; 0.29-0.96) were statistically significantly associated with an increased risk of mortality; ambulation and hearing were predictive for the 60+ cohort. Conclusion: Few studies have identified hearing or pain as risk factors for mortality. This study is innovative because it identifies specific components of HRQL that predict mortality. Further research is needed to understand better the mechanisms through which deficits in hearing and pain affect mortality risks.
AB - Objective: Measures of health-related quality of life (HRQL), including the Health Utilities Index Mark 3 (HUI3) are predictive of mortality. HUI3 includes eight attributes, vision, hearing, speech, ambulation, dexterity, cognition, emotion, and pain and discomfort, with five or six levels per attribute that vary from no to severe disability. This study examined associations between individual HUI3 attributes and mortality. Study Design and Setting: Baseline data and 12 years of follow-up data from a closed longitudinal cohort study, the 1994/95 Canadian National Population Health Survey, consisting of 12,375 women and men aged 18 and older. A priori hypotheses were that ambulation, cognition, emotion, and pain would predict mortality. Cox proportional hazards regression models were applied controlling for standard determinants of health and risk factors. Results: Single-attribute utility scores for ambulation (hazard ratio [HR] = 0.10; 0.04-0.22), hearing (HR = 0.18; 0.06-0.57), and pain (HR = 0.53; 0.29-0.96) were statistically significantly associated with an increased risk of mortality; ambulation and hearing were predictive for the 60+ cohort. Conclusion: Few studies have identified hearing or pain as risk factors for mortality. This study is innovative because it identifies specific components of HRQL that predict mortality. Further research is needed to understand better the mechanisms through which deficits in hearing and pain affect mortality risks.
KW - Health Utilities Index Mark 3
KW - Health-related quality of life
KW - Longitudinal
KW - Mortality
KW - Predictive validity
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U2 - 10.1016/j.jclinepi.2012.01.003
DO - 10.1016/j.jclinepi.2012.01.003
M3 - Article
C2 - 22521576
AN - SCOPUS:84861640603
SN - 0895-4356
VL - 65
SP - 764
EP - 777
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 7
ER -