Healthy lifestyles related to subsequent prevalence of age-related macular degeneration

Julie A. Mares, Rick P. Voland, Sherie A. Sondel, Amy E. Millen, Tara LaRowe, Suzen M. Moeller, Michael Klein, Barbara A. Blodi, Richard J. Chappell, Lesley Tinker, Cheryl Ritenbaugh, Karen M. Gehrs, Gloria E. Sarto, Elizabeth Johnson, D. Max Snodderly, Robert B. Wallace

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Objective: To investigate the relationships between lifestyle behaviors of diet, smoking, and physical activity and the subsequent prevalence of age-related macular degeneration (AMD). Methods: The population included 1313 participants (aged 55-74 years) in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative Observational Study. Scores on a modified 2005 Healthy Eating Index were assigned using responses to a food frequency questionnaire administered at baseline of the Women's Health Initiative Observational Study (1994-1998). Physical activity and lifetime smoking history were queried. An average of 6 years later, stereoscopic fundus photographs were taken to assess the presence and severity of AMD; it was present in 202 women, 94% of whom had early AMD, the primary outcome. Results: In multivariate models, women whose diets scored in the highest quintile compared with the lowest quintile on the modified 2005 Healthy Eating Index had 46% lower odds for early AMD. Women in the highest quintile compared with those in the lowest quintile for physical activity (in metabolic energy task hours per week) had 54% lower odds for early AMD. Although smoking was not independently associated with AMD on its own, having a combination of 3 healthy behaviors (healthy diet, physical activity, and not smoking) was associated with 71% lower odds for AMD compared with having highrisk scores (P

Original languageEnglish (US)
Pages (from-to)470-480
Number of pages11
JournalArchives of Ophthalmology
Volume129
Issue number4
DOIs
StatePublished - Apr 2011

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Macular Degeneration
Smoking
Exercise
Women's Health
Observational Studies
Diet
Eye Diseases
Carotenoids
Healthy Lifestyle
Life Style
History
Food
Population
Healthy Diet

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mares, J. A., Voland, R. P., Sondel, S. A., Millen, A. E., LaRowe, T., Moeller, S. M., ... Wallace, R. B. (2011). Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. Archives of Ophthalmology, 129(4), 470-480. https://doi.org/10.1001/archophthalmol.2010.314

Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. / Mares, Julie A.; Voland, Rick P.; Sondel, Sherie A.; Millen, Amy E.; LaRowe, Tara; Moeller, Suzen M.; Klein, Michael; Blodi, Barbara A.; Chappell, Richard J.; Tinker, Lesley; Ritenbaugh, Cheryl; Gehrs, Karen M.; Sarto, Gloria E.; Johnson, Elizabeth; Snodderly, D. Max; Wallace, Robert B.

In: Archives of Ophthalmology, Vol. 129, No. 4, 04.2011, p. 470-480.

Research output: Contribution to journalArticle

Mares, JA, Voland, RP, Sondel, SA, Millen, AE, LaRowe, T, Moeller, SM, Klein, M, Blodi, BA, Chappell, RJ, Tinker, L, Ritenbaugh, C, Gehrs, KM, Sarto, GE, Johnson, E, Snodderly, DM & Wallace, RB 2011, 'Healthy lifestyles related to subsequent prevalence of age-related macular degeneration', Archives of Ophthalmology, vol. 129, no. 4, pp. 470-480. https://doi.org/10.1001/archophthalmol.2010.314
Mares, Julie A. ; Voland, Rick P. ; Sondel, Sherie A. ; Millen, Amy E. ; LaRowe, Tara ; Moeller, Suzen M. ; Klein, Michael ; Blodi, Barbara A. ; Chappell, Richard J. ; Tinker, Lesley ; Ritenbaugh, Cheryl ; Gehrs, Karen M. ; Sarto, Gloria E. ; Johnson, Elizabeth ; Snodderly, D. Max ; Wallace, Robert B. / Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. In: Archives of Ophthalmology. 2011 ; Vol. 129, No. 4. pp. 470-480.
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