TY - JOUR
T1 - Health-Related Quality-of-Life Comparison of Adult Related and Unrelated HSC Donors
T2 - An RDSafe Study
AU - Switzer, Galen E.
AU - Bruce, Jessica G.
AU - Kiefer, Deidre M.
AU - Kobusingye, Hati
AU - Abebe, Kaleab Z.
AU - Drexler, Rebecca
AU - Besser, Rae Anne M.
AU - Confer, Dennis L.
AU - Horowitz, Mary M.
AU - King, Roberta J.
AU - Shaw, Bronwen E.
AU - Riches, Marcie
AU - Hayes-Lattin, Brandon
AU - Linenberger, Michael
AU - Bolwell, Brian
AU - Rowley, Scott D.
AU - Litzow, Mark R.
AU - Pulsipher, Michael A.
N1 - Funding Information:
Financial disclosure: Supported by a grant from the National Heart, Lung, and Blood Institute (NHLBI R01 HL085707). The contents do not reflect the views of the Department of Veterans Affairs or the US government.
Funding Information:
Financial disclosure: Supported by a grant from the National Heart, Lung, and Blood Institute (NHLBI R01 HL085707). The contents do not reflect the views of the Department of Veterans Affairs or the US government. Conflict of interest statement: There are no conflicts of interest to report. Authorship statement: J.B. collected and managed data at the University of Pittsburgh, assisted with data analysis, and contributed to the conceptual organization of the manuscript. D.M.K. H.K. R.D. R.M.B. D.L.C. M.M.H. R.J.K. and B.E.S. facilitated and managed sampling and participant recruitment and data management at the National Marrow Donor Program. M.A.P. recruited and monitored participating transplant centers. All authors participated in the design of the research, selection of the analytic strategy, and manuscript preparation; interpreted data; and reviewed and approved the final manuscript. Financial disclosure: See Acknowledgments on page 2370.
Publisher Copyright:
© 2020
PY - 2020/12
Y1 - 2020/12
N2 - Multiple investigations have documented the health-related quality-of-life (HRQoL) and donation-related experiences of unrelated donors (URDs), but similar investigations of the related donor (RD) experience have been less common. The central goal of this study was to longitudinally examine and compare HRQoL of RD and URD hematopoietic stem cell (HSC) donors from predonation through 1 year postdonation. This prospective investigation included adult HSC donors ages 18 to 60 years who donated bone marrow or peripheral blood stem cells at one of 48 geographically diverse US transplant/donor centers and completed HRQoL interviews at predonation and 4 weeks and 1 year postdonation. At predonation, related donors were less ambivalent about donation (t = –3.30; P = .001), more satisfied with their decision to donate (t = 2.65; P = .009), and more likely to define themselves as donors (t = 2.94; P = .004) than were URDs. However, related donors were more concerned about the use of needles (odds ratio [OR] = 2.19; P = .012), about who would pay for the procedure (OR = 2.80; P = .011), and the possibility that they would feel responsible if the transplant failed (t = 2.31; P = .022). Shortly postdonation, related donors were more likely to report donation-related pain (t = 2.50; P = .013) and lightheadedness (OR = 3.63; P = .028). At 1 year postdonation, related donors were less likely to be fully recovered from donation (OR = 0.10; P = .010) and more likely to report a longer recovery period following donation (t = 2.57; P = .011), although this latter finding was primarily due to the percentage of related versus unrelated donors not fully recovered at 1 year postdonation (10% versus 1%). Taken together, these findings suggest that current related donor management practices may be sufficient in preparing related donors for the psychological aspects of donation but that there may be more to do in terms of calibrating the description of donation-related experiences and recovery time to the related donor group (i.e., descriptions of donation experiences based on unrelated donation may not provide best estimates of experience for this group).
AB - Multiple investigations have documented the health-related quality-of-life (HRQoL) and donation-related experiences of unrelated donors (URDs), but similar investigations of the related donor (RD) experience have been less common. The central goal of this study was to longitudinally examine and compare HRQoL of RD and URD hematopoietic stem cell (HSC) donors from predonation through 1 year postdonation. This prospective investigation included adult HSC donors ages 18 to 60 years who donated bone marrow or peripheral blood stem cells at one of 48 geographically diverse US transplant/donor centers and completed HRQoL interviews at predonation and 4 weeks and 1 year postdonation. At predonation, related donors were less ambivalent about donation (t = –3.30; P = .001), more satisfied with their decision to donate (t = 2.65; P = .009), and more likely to define themselves as donors (t = 2.94; P = .004) than were URDs. However, related donors were more concerned about the use of needles (odds ratio [OR] = 2.19; P = .012), about who would pay for the procedure (OR = 2.80; P = .011), and the possibility that they would feel responsible if the transplant failed (t = 2.31; P = .022). Shortly postdonation, related donors were more likely to report donation-related pain (t = 2.50; P = .013) and lightheadedness (OR = 3.63; P = .028). At 1 year postdonation, related donors were less likely to be fully recovered from donation (OR = 0.10; P = .010) and more likely to report a longer recovery period following donation (t = 2.57; P = .011), although this latter finding was primarily due to the percentage of related versus unrelated donors not fully recovered at 1 year postdonation (10% versus 1%). Taken together, these findings suggest that current related donor management practices may be sufficient in preparing related donors for the psychological aspects of donation but that there may be more to do in terms of calibrating the description of donation-related experiences and recovery time to the related donor group (i.e., descriptions of donation experiences based on unrelated donation may not provide best estimates of experience for this group).
KW - HSC donation
KW - HSC donor HRQoL
KW - Related versus unrelated donation
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U2 - 10.1016/j.bbmt.2020.08.016
DO - 10.1016/j.bbmt.2020.08.016
M3 - Article
C2 - 32829080
AN - SCOPUS:85091208680
SN - 1083-8791
VL - 26
SP - 2365
EP - 2371
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 12
ER -