Health-Related Quality of Life among Older Related Hematopoietic Stem Cell Donors (>60 Years) Is Equivalent to That of Younger Related Donors (18 to 60 Years): A Related Donor Safety Study

Galen E. Switzer, Jessica Bruce, Deidre M. Kiefer, Hati Kobusingye, Rebecca Drexler, Rae Anne M Besser, Dennis L. Confer, Mary M. Horowitz, Roberta J. King, Bronwen E. Shaw, Marcie Riches, Brandon Hayes-Lattin, Michael Linenberger, Brian Bolwell, Scott D. Rowley, Mark R. Litzow, Michael A. Pulsipher

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The increasing number of older adults with blood-related disorders and the introduction of reduced-intensity conditioning regimens has led to increases in hematopoietic stem cell (HSC) transplantation among older adults and a corresponding increase in the age of siblings who donate HSCs to these patients. Data regarding the donation-related experiences of older donors are lacking. The Related Donor Safety Study aimed to examine/compare health-related quality of life (HRQoL) of older versus younger HSC donors. Sixty peripheral blood stem cell (PBSC) donors ages 18 to 60 years and 104 PBSC donors age >60 years completed validated questionnaires before donation and 4 weeks and 1 year after donation. Before donation, older donors had poorer general physical health (t = −3.27; P = .001) but better mental health (t = 2.11; P < .05). There were no age differences in multiple other donation-related factors. At 4 weeks after donation, there were no group differences in general physical/mental health, but older donors were less likely to report donation-related pain (t = −2.26; P < .05) and concerns (t = −3.38; P = .001). At both 4 weeks and 1 year after donation, there were no significant differences in the percentage of each age group feeling physically back to normal or in the number of days it took donors to feel completely well. There was no evidence that increasing age within the older donor group was associated with poorer donation-related HRQoL. Taken together, these data support the current practice of HSC donation by sibling donors above age 60, providing no evidence of worsening HRQoL up to 1 year after donation in individuals up to age 76.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Hematopoietic Stem Cells
Quality of Life
Tissue Donors
Safety
Siblings
Mental Health
Hematopoietic Stem Cell Transplantation
Emotions
Age Groups
Pain
Health

Keywords

  • Hematopoietic stem cell (HSC) donation
  • HSC donor health-related quality of life (HRQoL)
  • Related donation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Health-Related Quality of Life among Older Related Hematopoietic Stem Cell Donors (>60 Years) Is Equivalent to That of Younger Related Donors (18 to 60 Years) : A Related Donor Safety Study. / Switzer, Galen E.; Bruce, Jessica; Kiefer, Deidre M.; Kobusingye, Hati; Drexler, Rebecca; Besser, Rae Anne M; Confer, Dennis L.; Horowitz, Mary M.; King, Roberta J.; Shaw, Bronwen E.; Riches, Marcie; Hayes-Lattin, Brandon; Linenberger, Michael; Bolwell, Brian; Rowley, Scott D.; Litzow, Mark R.; Pulsipher, Michael A.

In: Biology of Blood and Marrow Transplantation, Vol. 23, No. 1, 01.01.2017, p. 165-171.

Research output: Contribution to journalArticle

Switzer, GE, Bruce, J, Kiefer, DM, Kobusingye, H, Drexler, R, Besser, RAM, Confer, DL, Horowitz, MM, King, RJ, Shaw, BE, Riches, M, Hayes-Lattin, B, Linenberger, M, Bolwell, B, Rowley, SD, Litzow, MR & Pulsipher, MA 2017, 'Health-Related Quality of Life among Older Related Hematopoietic Stem Cell Donors (>60 Years) Is Equivalent to That of Younger Related Donors (18 to 60 Years): A Related Donor Safety Study', Biology of Blood and Marrow Transplantation, vol. 23, no. 1, pp. 165-171. https://doi.org/10.1016/j.bbmt.2016.10.008
Switzer, Galen E. ; Bruce, Jessica ; Kiefer, Deidre M. ; Kobusingye, Hati ; Drexler, Rebecca ; Besser, Rae Anne M ; Confer, Dennis L. ; Horowitz, Mary M. ; King, Roberta J. ; Shaw, Bronwen E. ; Riches, Marcie ; Hayes-Lattin, Brandon ; Linenberger, Michael ; Bolwell, Brian ; Rowley, Scott D. ; Litzow, Mark R. ; Pulsipher, Michael A. / Health-Related Quality of Life among Older Related Hematopoietic Stem Cell Donors (>60 Years) Is Equivalent to That of Younger Related Donors (18 to 60 Years) : A Related Donor Safety Study. In: Biology of Blood and Marrow Transplantation. 2017 ; Vol. 23, No. 1. pp. 165-171.
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