Health care-associated invasive MRSA infections, 2005-2008

Alexander J. Kallen, Yi Mu, Sandra Bulens, Arthur Reingold, Susan Petit, Ken Gershman, Susan M. Ray, Lee H. Harrison, Ruth Lynfield, Ghinwa Dumyati, John Townes, William Schaffner, Priti R. Patel, Scott K. Fridkin

Research output: Contribution to journalArticle

314 Citations (Scopus)

Abstract

Context: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen of public health importance; MRSA prevention programs that may affect MRSA transmission and infection are increasingly common in health care settings. Whether there have been changes in MRSA infection incidence as these programs become established is unknown; however, recent data have shown that rates of MRSA bloodstream infections (BSIs) in intensive care units are decreasing. Objective: To describe changes in rates of invasive health care-associated MRSA infections from 2005 through 2008 among residents of 9 US metropolitan areas. Design, Setting, and Participants: Active, population-based surveillance for invasive MRSA in 9 metropolitan areas covering a population of approximately 15 million persons. All reports of laboratory-identified episodes of invasive (from a normally sterile body site) MRSA infections from 2005 through 2008 were evaluated and classified based on the setting of the positive culture and the presence or absence of health care exposures. Health care-associated infections (ie, hospital-onset and health care-associated community-onset), which made up 82% of the total infections, were included in this analysis. Main Outcome Measures: Change in incidence of invasive health care-associated MRSA infections and health care-associated MRSA BSIs using population of the catchment area as the denominator. Results: From 2005 through 2008, there were 21 503 episodes of invasive MRSA infection; 17 508 were health care associated. Of these, 15 458 were MRSA BSIs. The incidence rate of hospital-onset invasive MRSA infections was 1.02 per 10 000 population in 2005 and decreased 9.4% per year (95% confidence interval [CI], 14.7% to 3.8%; P=.005), and the incidence of health care-associated community-onset infections was 2.20 per 10 000 population in 2005 and decreased 5.7% per year (95% CI, 9.7% to 1.6%; P=.01). The decrease was most prominent for the subset of infections with BSIs (hospital-onset: -11.2%; 95% CI -15.9% to -6.3%; health care-associated community-onset: -6.6%; 95% CI -9.5% to -3.7%). Conclusion: Over the 4-year period from 2005 through 2008 in 9 diverse metropolitan areas, rates of invasive health care-associated MRSA infections decreased among patients with health care-associated infections that began in the community and also decreased among those with hospital-onset invasive disease.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalJAMA - Journal of the American Medical Association
Volume304
Issue number6
DOIs
StatePublished - Aug 11 2010

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Methicillin-Resistant Staphylococcus aureus
Delivery of Health Care
Infection
Cross Infection
Confidence Intervals
Incidence
Population
Population Surveillance
Infectious Disease Transmission
Intensive Care Units
Public Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kallen, A. J., Mu, Y., Bulens, S., Reingold, A., Petit, S., Gershman, K., ... Fridkin, S. K. (2010). Health care-associated invasive MRSA infections, 2005-2008. JAMA - Journal of the American Medical Association, 304(6), 641-648. https://doi.org/10.1001/jama.2010.1115

Health care-associated invasive MRSA infections, 2005-2008. / Kallen, Alexander J.; Mu, Yi; Bulens, Sandra; Reingold, Arthur; Petit, Susan; Gershman, Ken; Ray, Susan M.; Harrison, Lee H.; Lynfield, Ruth; Dumyati, Ghinwa; Townes, John; Schaffner, William; Patel, Priti R.; Fridkin, Scott K.

In: JAMA - Journal of the American Medical Association, Vol. 304, No. 6, 11.08.2010, p. 641-648.

Research output: Contribution to journalArticle

Kallen, AJ, Mu, Y, Bulens, S, Reingold, A, Petit, S, Gershman, K, Ray, SM, Harrison, LH, Lynfield, R, Dumyati, G, Townes, J, Schaffner, W, Patel, PR & Fridkin, SK 2010, 'Health care-associated invasive MRSA infections, 2005-2008', JAMA - Journal of the American Medical Association, vol. 304, no. 6, pp. 641-648. https://doi.org/10.1001/jama.2010.1115
Kallen AJ, Mu Y, Bulens S, Reingold A, Petit S, Gershman K et al. Health care-associated invasive MRSA infections, 2005-2008. JAMA - Journal of the American Medical Association. 2010 Aug 11;304(6):641-648. https://doi.org/10.1001/jama.2010.1115
Kallen, Alexander J. ; Mu, Yi ; Bulens, Sandra ; Reingold, Arthur ; Petit, Susan ; Gershman, Ken ; Ray, Susan M. ; Harrison, Lee H. ; Lynfield, Ruth ; Dumyati, Ghinwa ; Townes, John ; Schaffner, William ; Patel, Priti R. ; Fridkin, Scott K. / Health care-associated invasive MRSA infections, 2005-2008. In: JAMA - Journal of the American Medical Association. 2010 ; Vol. 304, No. 6. pp. 641-648.
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abstract = "Context: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen of public health importance; MRSA prevention programs that may affect MRSA transmission and infection are increasingly common in health care settings. Whether there have been changes in MRSA infection incidence as these programs become established is unknown; however, recent data have shown that rates of MRSA bloodstream infections (BSIs) in intensive care units are decreasing. Objective: To describe changes in rates of invasive health care-associated MRSA infections from 2005 through 2008 among residents of 9 US metropolitan areas. Design, Setting, and Participants: Active, population-based surveillance for invasive MRSA in 9 metropolitan areas covering a population of approximately 15 million persons. All reports of laboratory-identified episodes of invasive (from a normally sterile body site) MRSA infections from 2005 through 2008 were evaluated and classified based on the setting of the positive culture and the presence or absence of health care exposures. Health care-associated infections (ie, hospital-onset and health care-associated community-onset), which made up 82{\%} of the total infections, were included in this analysis. Main Outcome Measures: Change in incidence of invasive health care-associated MRSA infections and health care-associated MRSA BSIs using population of the catchment area as the denominator. Results: From 2005 through 2008, there were 21 503 episodes of invasive MRSA infection; 17 508 were health care associated. Of these, 15 458 were MRSA BSIs. The incidence rate of hospital-onset invasive MRSA infections was 1.02 per 10 000 population in 2005 and decreased 9.4{\%} per year (95{\%} confidence interval [CI], 14.7{\%} to 3.8{\%}; P=.005), and the incidence of health care-associated community-onset infections was 2.20 per 10 000 population in 2005 and decreased 5.7{\%} per year (95{\%} CI, 9.7{\%} to 1.6{\%}; P=.01). The decrease was most prominent for the subset of infections with BSIs (hospital-onset: -11.2{\%}; 95{\%} CI -15.9{\%} to -6.3{\%}; health care-associated community-onset: -6.6{\%}; 95{\%} CI -9.5{\%} to -3.7{\%}). Conclusion: Over the 4-year period from 2005 through 2008 in 9 diverse metropolitan areas, rates of invasive health care-associated MRSA infections decreased among patients with health care-associated infections that began in the community and also decreased among those with hospital-onset invasive disease.",
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AU - Kallen, Alexander J.

AU - Mu, Yi

AU - Bulens, Sandra

AU - Reingold, Arthur

AU - Petit, Susan

AU - Gershman, Ken

AU - Ray, Susan M.

AU - Harrison, Lee H.

AU - Lynfield, Ruth

AU - Dumyati, Ghinwa

AU - Townes, John

AU - Schaffner, William

AU - Patel, Priti R.

AU - Fridkin, Scott K.

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N2 - Context: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen of public health importance; MRSA prevention programs that may affect MRSA transmission and infection are increasingly common in health care settings. Whether there have been changes in MRSA infection incidence as these programs become established is unknown; however, recent data have shown that rates of MRSA bloodstream infections (BSIs) in intensive care units are decreasing. Objective: To describe changes in rates of invasive health care-associated MRSA infections from 2005 through 2008 among residents of 9 US metropolitan areas. Design, Setting, and Participants: Active, population-based surveillance for invasive MRSA in 9 metropolitan areas covering a population of approximately 15 million persons. All reports of laboratory-identified episodes of invasive (from a normally sterile body site) MRSA infections from 2005 through 2008 were evaluated and classified based on the setting of the positive culture and the presence or absence of health care exposures. Health care-associated infections (ie, hospital-onset and health care-associated community-onset), which made up 82% of the total infections, were included in this analysis. Main Outcome Measures: Change in incidence of invasive health care-associated MRSA infections and health care-associated MRSA BSIs using population of the catchment area as the denominator. Results: From 2005 through 2008, there were 21 503 episodes of invasive MRSA infection; 17 508 were health care associated. Of these, 15 458 were MRSA BSIs. The incidence rate of hospital-onset invasive MRSA infections was 1.02 per 10 000 population in 2005 and decreased 9.4% per year (95% confidence interval [CI], 14.7% to 3.8%; P=.005), and the incidence of health care-associated community-onset infections was 2.20 per 10 000 population in 2005 and decreased 5.7% per year (95% CI, 9.7% to 1.6%; P=.01). The decrease was most prominent for the subset of infections with BSIs (hospital-onset: -11.2%; 95% CI -15.9% to -6.3%; health care-associated community-onset: -6.6%; 95% CI -9.5% to -3.7%). Conclusion: Over the 4-year period from 2005 through 2008 in 9 diverse metropolitan areas, rates of invasive health care-associated MRSA infections decreased among patients with health care-associated infections that began in the community and also decreased among those with hospital-onset invasive disease.

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