Healing of deep venous thrombosis: Venographic findings in a randomized study comparing streptokinase and heparin

J. Rosch, C. T. Dotter, A. J. Seaman, J. M. Porter, H. H. Common

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Sequential ascending venographic studies were used to assess the healing of deep venous thrombosis in 50 patients randomly assigned to streptokinase or heparin therapy. Various degrees of thrombolysis and/or recanalization were demonstrated by venograms performed on the fourth and tenth days of treatment. Late follow up studies (mean, 7 months after treatment) showed three basic patterns of resolution: (1) return to normal, (2) complete recanalization, and (3) incomplete recanalization and/or collateralization. Loss of valves or their function was associated with recanalization. The character, speed, and outcome of healing reflected the nature and extent of thrombosis, prior thrombotic disease in the extremity, the the type and timing of treatment. Streptokinase was highly effective and preferable to heparin in patients with deep vein thrombosis when therapy was begun within 4 days of onset of symptoms. In later stages of acute or recurrent deep vein thrombosis, the effectiveness of both drugs was significantly reduced.

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalUnknown Journal
Volume127
Issue number4
DOIs
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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