HDAC3 at the Fulcrum of an Epithelial-Mesenchymal Balance

Sendurai A. Mani, Michelle Craig Barton

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

In this issue of Molecular Cell, Wu et al. (2011) reveal an essential role for a chromatin modifier, histone deacetylase 3 (HDAC3), in hypoxia-induced epithelial-mesenchymal transition (EMT); HIF-activated HDAC3 integrates with WDR5 to impose chromatin modifications that culminate in EMT.

Original languageEnglish (US)
Pages (from-to)697-698
Number of pages2
JournalMolecular Cell
Volume43
Issue number5
DOIs
StatePublished - Sep 2 2011
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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