Have we found the tip link, transduction channel, and gating spring of the hair cell?

Peter Barr-Gillespie, Rachel A. Dumont, Bechara Kachar

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Recent reports have offered candidates for key components of the apparatus used for mechanotransduction in hair cells. TRPA1 and cadherin 23 have been proposed to be the transduction channel and component of the tip link, respectively; moreover, ankyrin repeats in TRPA1 have been proposed to be the gating spring. Although these are excellent candidates for the three components, definitive experiments supporting each identification have yet to be performed.

Original languageEnglish (US)
Pages (from-to)389-396
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume15
Issue number4
DOIs
StatePublished - Aug 2005

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Ankyrin Repeat
Cadherins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Have we found the tip link, transduction channel, and gating spring of the hair cell? / Barr-Gillespie, Peter; Dumont, Rachel A.; Kachar, Bechara.

In: Current Opinion in Neurobiology, Vol. 15, No. 4, 08.2005, p. 389-396.

Research output: Contribution to journalArticle

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