Have we found the tip link, transduction channel, and gating spring of the hair cell?

Peter G. Gillespie, Rachel A. Dumont, Bechara Kachar

Research output: Contribution to journalReview article

48 Scopus citations


Recent reports have offered candidates for key components of the apparatus used for mechanotransduction in hair cells. TRPA1 and cadherin 23 have been proposed to be the transduction channel and component of the tip link, respectively; moreover, ankyrin repeats in TRPA1 have been proposed to be the gating spring. Although these are excellent candidates for the three components, definitive experiments supporting each identification have yet to be performed.

Original languageEnglish (US)
Pages (from-to)389-396
Number of pages8
JournalCurrent Opinion in Neurobiology
Issue number4
StatePublished - Aug 1 2005


ASJC Scopus subject areas

  • Neuroscience(all)

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