Harmful somatic mutations

Lessons from the dark side

Gregory D. Wiens, Victoria A. Roberts, Elizabeth A. Whitcomb, Thomas O'Hare, Mary Stenzel-Poore, Marvin Rittenberg

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The ability of somatic mutation to modify the course of an immune response is well documented. However, emphasis has been placed almost exclusively on the ability of somatic mutation to improve the functional characteristics of representative antibodies. The harmful effects of somatic mutation, its dark side, have been far less well characterized. Yet evidence suggests that the number of B cells directed to wastage pathways as a result of harmful somatic mutation probably far exceeds the number of cells whose antibodies have been improved. Here we review our recent findings in understanding the structural and functional consequences of V-region mutation.

Original languageEnglish (US)
Pages (from-to)197-209
Number of pages13
JournalImmunological Reviews
Volume162
DOIs
StatePublished - Apr 1998

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Mutation
Antibodies
B-Lymphocytes
Cell Count

ASJC Scopus subject areas

  • Immunology

Cite this

Wiens, G. D., Roberts, V. A., Whitcomb, E. A., O'Hare, T., Stenzel-Poore, M., & Rittenberg, M. (1998). Harmful somatic mutations: Lessons from the dark side. Immunological Reviews, 162, 197-209. https://doi.org/10.1111/j.1600-065X.1998.tb01442.x

Harmful somatic mutations : Lessons from the dark side. / Wiens, Gregory D.; Roberts, Victoria A.; Whitcomb, Elizabeth A.; O'Hare, Thomas; Stenzel-Poore, Mary; Rittenberg, Marvin.

In: Immunological Reviews, Vol. 162, 04.1998, p. 197-209.

Research output: Contribution to journalArticle

Wiens, GD, Roberts, VA, Whitcomb, EA, O'Hare, T, Stenzel-Poore, M & Rittenberg, M 1998, 'Harmful somatic mutations: Lessons from the dark side', Immunological Reviews, vol. 162, pp. 197-209. https://doi.org/10.1111/j.1600-065X.1998.tb01442.x
Wiens, Gregory D. ; Roberts, Victoria A. ; Whitcomb, Elizabeth A. ; O'Hare, Thomas ; Stenzel-Poore, Mary ; Rittenberg, Marvin. / Harmful somatic mutations : Lessons from the dark side. In: Immunological Reviews. 1998 ; Vol. 162. pp. 197-209.
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