Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The author presents a patient with Harlequin and Horner syndromes as part of an autoimmune autonomic ganglionopathy and suggests implication for work-up and management. In general, Harlequin and Horner syndromes are reported to be caused by either a structural lesion of the sympathetic pathway or, when no structural lesion is found, are presumed to be idiopathic. In this paper, a 76 year old man developed a Harlequin and Horner syndromes in the setting of subacute autonomic failure and other systemic features. The patient's symptoms improved with a short course of intravenous methylprednisolone. An autoimmune etiology should be considered in patients with Harlequin syndrome and immunomodulatory treatment could be attempted, especially when there is evidence of a more generalized autoimmune autonomic ganglionopathy.

Original languageEnglish (US)
Pages (from-to)58-59
Number of pages2
JournalAutonomic Neuroscience: Basic and Clinical
Volume194
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Horner Syndrome
Methylprednisolone
Harlequin syndrome
Therapeutics

Keywords

  • All Immunology
  • Autoimmune diseases
  • Dysautonomia
  • Harlequin syndrome
  • Horner's

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy. / Karam, Chafic.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 194, 01.01.2016, p. 58-59.

Research output: Contribution to journalArticle

@article{95d4aa7b3a574d1e84bb3db2dc12c661,
title = "Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy",
abstract = "The author presents a patient with Harlequin and Horner syndromes as part of an autoimmune autonomic ganglionopathy and suggests implication for work-up and management. In general, Harlequin and Horner syndromes are reported to be caused by either a structural lesion of the sympathetic pathway or, when no structural lesion is found, are presumed to be idiopathic. In this paper, a 76 year old man developed a Harlequin and Horner syndromes in the setting of subacute autonomic failure and other systemic features. The patient's symptoms improved with a short course of intravenous methylprednisolone. An autoimmune etiology should be considered in patients with Harlequin syndrome and immunomodulatory treatment could be attempted, especially when there is evidence of a more generalized autoimmune autonomic ganglionopathy.",
keywords = "All Immunology, Autoimmune diseases, Dysautonomia, Harlequin syndrome, Horner's",
author = "Chafic Karam",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.autneu.2015.12.004",
language = "English (US)",
volume = "194",
pages = "58--59",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",

}

TY - JOUR

T1 - Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy

AU - Karam, Chafic

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The author presents a patient with Harlequin and Horner syndromes as part of an autoimmune autonomic ganglionopathy and suggests implication for work-up and management. In general, Harlequin and Horner syndromes are reported to be caused by either a structural lesion of the sympathetic pathway or, when no structural lesion is found, are presumed to be idiopathic. In this paper, a 76 year old man developed a Harlequin and Horner syndromes in the setting of subacute autonomic failure and other systemic features. The patient's symptoms improved with a short course of intravenous methylprednisolone. An autoimmune etiology should be considered in patients with Harlequin syndrome and immunomodulatory treatment could be attempted, especially when there is evidence of a more generalized autoimmune autonomic ganglionopathy.

AB - The author presents a patient with Harlequin and Horner syndromes as part of an autoimmune autonomic ganglionopathy and suggests implication for work-up and management. In general, Harlequin and Horner syndromes are reported to be caused by either a structural lesion of the sympathetic pathway or, when no structural lesion is found, are presumed to be idiopathic. In this paper, a 76 year old man developed a Harlequin and Horner syndromes in the setting of subacute autonomic failure and other systemic features. The patient's symptoms improved with a short course of intravenous methylprednisolone. An autoimmune etiology should be considered in patients with Harlequin syndrome and immunomodulatory treatment could be attempted, especially when there is evidence of a more generalized autoimmune autonomic ganglionopathy.

KW - All Immunology

KW - Autoimmune diseases

KW - Dysautonomia

KW - Harlequin syndrome

KW - Horner's

UR - http://www.scopus.com/inward/record.url?scp=84983210814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983210814&partnerID=8YFLogxK

U2 - 10.1016/j.autneu.2015.12.004

DO - 10.1016/j.autneu.2015.12.004

M3 - Article

C2 - 26704065

AN - SCOPUS:84983210814

VL - 194

SP - 58

EP - 59

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

ER -