Harderian gland pathology in transgenic mice carrying the MMTV/v-Ha-ras gene

V. White, E. Sinn, D. M. Albert

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Twenty-four Harderian glands from 16 transgenic mice carrying a v-Ha-ras gene under the control of the mouse mammary tumor virus promoter were examined histologically upon death of the animals. Eight glands were histologically normal and eleven were hyperplastic. Four additional glands showed predominantly hyperplasia, but also contained foci of dysplasia and in situ carcinoma. One gland contained an adenocarcinoma. The range of pathology observed in the Harderian glands of these transgenic mice was similar to that which arises spontaneously, although hyperplasia, and not adenoma, occurred in these mice as the benign tumor.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume31
Issue number3
StatePublished - Jan 1 1990

Keywords

  • Harderian gland
  • Oncogene
  • Orbital neoplasm
  • Transgenic mouse
  • v-Ha-ras

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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