Hard-palate mucosa graft in Stevens-Johnson syndrome

G. E. Mannor, William Mathers, D. E. Wolfley, J. A. Martinez

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

PURPOSE: We evaluated the use of hard-palate mucosa grafts in the treatment of cicatricial entropion and trichiasis associated with Stevens- Johnson syndrome. METHODS: Six patients, two men and four women, were treated with hard-palate mucosa grafts of one or more eyelids with cicatricial entropion, trichiasis, and corneal disease. The follow-up ranged from 19 to 33 months. RESULTS: Visual acuity improved in one of nine eyes and remained stable in the rest. Corneal epithelial disease improved in eight of nine eyes, while in one eye the epithelial defect stabilized. The corneal epithelium of all three corneal transplants remained intact, although one of these patients underwent another corneal transplantation and the other two transplants opacified from rejection. Cicatricial entropion resolved and symblephara improved in all 16 eyelids. Trichiasis resolved or improved in 12 of 16 eyelids and remained stable in the other eyelids. CONCLUSIONS: The chronic relapsing nature of Stevens-Johnson syndrome requires caution in interpreting surgical intervention in the treatment of dysfunctional eyelids. However, hard-palate grafts may be considered for patients with the Stevens- Johnson syndrome and severe ocular surface disease.

Original languageEnglish (US)
Pages (from-to)786-791
Number of pages6
JournalAmerican Journal of Ophthalmology
Volume118
Issue number6
StatePublished - 1994
Externally publishedYes

Fingerprint

Hard Palate
Stevens-Johnson Syndrome
Eyelids
Trichiasis
Entropion
Mucous Membrane
Transplants
Corneal Diseases
Corneal Epithelium
Corneal Transplantation
Eye Diseases
Graft Rejection
Visual Acuity
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mannor, G. E., Mathers, W., Wolfley, D. E., & Martinez, J. A. (1994). Hard-palate mucosa graft in Stevens-Johnson syndrome. American Journal of Ophthalmology, 118(6), 786-791.

Hard-palate mucosa graft in Stevens-Johnson syndrome. / Mannor, G. E.; Mathers, William; Wolfley, D. E.; Martinez, J. A.

In: American Journal of Ophthalmology, Vol. 118, No. 6, 1994, p. 786-791.

Research output: Contribution to journalArticle

Mannor, GE, Mathers, W, Wolfley, DE & Martinez, JA 1994, 'Hard-palate mucosa graft in Stevens-Johnson syndrome', American Journal of Ophthalmology, vol. 118, no. 6, pp. 786-791.
Mannor, G. E. ; Mathers, William ; Wolfley, D. E. ; Martinez, J. A. / Hard-palate mucosa graft in Stevens-Johnson syndrome. In: American Journal of Ophthalmology. 1994 ; Vol. 118, No. 6. pp. 786-791.
@article{d3b32d17bff74fa68326ec5f3e389181,
title = "Hard-palate mucosa graft in Stevens-Johnson syndrome",
abstract = "PURPOSE: We evaluated the use of hard-palate mucosa grafts in the treatment of cicatricial entropion and trichiasis associated with Stevens- Johnson syndrome. METHODS: Six patients, two men and four women, were treated with hard-palate mucosa grafts of one or more eyelids with cicatricial entropion, trichiasis, and corneal disease. The follow-up ranged from 19 to 33 months. RESULTS: Visual acuity improved in one of nine eyes and remained stable in the rest. Corneal epithelial disease improved in eight of nine eyes, while in one eye the epithelial defect stabilized. The corneal epithelium of all three corneal transplants remained intact, although one of these patients underwent another corneal transplantation and the other two transplants opacified from rejection. Cicatricial entropion resolved and symblephara improved in all 16 eyelids. Trichiasis resolved or improved in 12 of 16 eyelids and remained stable in the other eyelids. CONCLUSIONS: The chronic relapsing nature of Stevens-Johnson syndrome requires caution in interpreting surgical intervention in the treatment of dysfunctional eyelids. However, hard-palate grafts may be considered for patients with the Stevens- Johnson syndrome and severe ocular surface disease.",
author = "Mannor, {G. E.} and William Mathers and Wolfley, {D. E.} and Martinez, {J. A.}",
year = "1994",
language = "English (US)",
volume = "118",
pages = "786--791",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Hard-palate mucosa graft in Stevens-Johnson syndrome

AU - Mannor, G. E.

AU - Mathers, William

AU - Wolfley, D. E.

AU - Martinez, J. A.

PY - 1994

Y1 - 1994

N2 - PURPOSE: We evaluated the use of hard-palate mucosa grafts in the treatment of cicatricial entropion and trichiasis associated with Stevens- Johnson syndrome. METHODS: Six patients, two men and four women, were treated with hard-palate mucosa grafts of one or more eyelids with cicatricial entropion, trichiasis, and corneal disease. The follow-up ranged from 19 to 33 months. RESULTS: Visual acuity improved in one of nine eyes and remained stable in the rest. Corneal epithelial disease improved in eight of nine eyes, while in one eye the epithelial defect stabilized. The corneal epithelium of all three corneal transplants remained intact, although one of these patients underwent another corneal transplantation and the other two transplants opacified from rejection. Cicatricial entropion resolved and symblephara improved in all 16 eyelids. Trichiasis resolved or improved in 12 of 16 eyelids and remained stable in the other eyelids. CONCLUSIONS: The chronic relapsing nature of Stevens-Johnson syndrome requires caution in interpreting surgical intervention in the treatment of dysfunctional eyelids. However, hard-palate grafts may be considered for patients with the Stevens- Johnson syndrome and severe ocular surface disease.

AB - PURPOSE: We evaluated the use of hard-palate mucosa grafts in the treatment of cicatricial entropion and trichiasis associated with Stevens- Johnson syndrome. METHODS: Six patients, two men and four women, were treated with hard-palate mucosa grafts of one or more eyelids with cicatricial entropion, trichiasis, and corneal disease. The follow-up ranged from 19 to 33 months. RESULTS: Visual acuity improved in one of nine eyes and remained stable in the rest. Corneal epithelial disease improved in eight of nine eyes, while in one eye the epithelial defect stabilized. The corneal epithelium of all three corneal transplants remained intact, although one of these patients underwent another corneal transplantation and the other two transplants opacified from rejection. Cicatricial entropion resolved and symblephara improved in all 16 eyelids. Trichiasis resolved or improved in 12 of 16 eyelids and remained stable in the other eyelids. CONCLUSIONS: The chronic relapsing nature of Stevens-Johnson syndrome requires caution in interpreting surgical intervention in the treatment of dysfunctional eyelids. However, hard-palate grafts may be considered for patients with the Stevens- Johnson syndrome and severe ocular surface disease.

UR - http://www.scopus.com/inward/record.url?scp=0028046349&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028046349&partnerID=8YFLogxK

M3 - Article

C2 - 7977606

AN - SCOPUS:0028046349

VL - 118

SP - 786

EP - 791

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 6

ER -