Handling induced convulsions in twenty inbred strains of mice

John Jr Crabbe, J. S. Janowsky, E. R. Young, H. Rigter

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Male mice of twenty highly inbred strains were tested for handling-induced convulsions according to the method of Goldstein. In eight of the strains, all mice always showed mild convulsions. In five strains, no mice convulsed. The other seven strains yielded intermediate scores. Many studies of dependence on ethanol rely on this symptom to index withdrawal reactions. Studies of strain differences in dependence on ethanol should take into account preexisting strain differences in seizure susceptibility.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalSubstance and Alcohol Actions/Misuse
Volume1
Issue number2
StatePublished - 1980
Externally publishedYes

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Inbred Strains Mice
Seizures
seizure
Ethanol
withdrawal

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Handling induced convulsions in twenty inbred strains of mice. / Crabbe, John Jr; Janowsky, J. S.; Young, E. R.; Rigter, H.

In: Substance and Alcohol Actions/Misuse, Vol. 1, No. 2, 1980, p. 159-163.

Research output: Contribution to journalArticle

Crabbe, JJ, Janowsky, JS, Young, ER & Rigter, H 1980, 'Handling induced convulsions in twenty inbred strains of mice', Substance and Alcohol Actions/Misuse, vol. 1, no. 2, pp. 159-163.
Crabbe, John Jr ; Janowsky, J. S. ; Young, E. R. ; Rigter, H. / Handling induced convulsions in twenty inbred strains of mice. In: Substance and Alcohol Actions/Misuse. 1980 ; Vol. 1, No. 2. pp. 159-163.
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