Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS)

T. K. Akers, John Belknap

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

The onset of hyperexcitability induced by HPNS in humans is easily determined by the disruption of simple motor tasks. We report here an adaptation of HIC for use in a sealed hyperbaric chamber on mice. Since these convulsions are elicited by lifting the mice by the tail, we developed a prototype apparatus which allows freedom of movement by the animals, yet the animals can be lifted at any desired interval by means of a fully proportional servo (Futaba FP-S48) actuated by a joy stick outside the chamber. Handling-induced convulsion scores were elevated by high pressure in heliox at pressures as low as 20 atmospheres, which is well below the thresholds for spontaneous clonic or tonic-clonic convulsions. This technique is especially useful in making direct comparisons between the hyperexcitability states associated with high pressure and those associated with alcohol and other drug withdrawal syndromes, where HIC is the predominant withdrawal sign.

Original languageEnglish (US)
Title of host publicationBiomedical Sciences Instrumentation
PublisherPubl by Marcel Dekker
Pages225-230
Number of pages6
Volume24
StatePublished - 1988
Externally publishedYes
EventProceedings of the Twenty-Fifth Annual Rocky Mountain Bioengineering Symposium and the Twenty-Fifth International ISA Biomedical Sciences Instrumentation Symposium - Colorado Spring, CO, USA
Duration: Apr 25 1988Apr 26 1988

Other

OtherProceedings of the Twenty-Fifth Annual Rocky Mountain Bioengineering Symposium and the Twenty-Fifth International ISA Biomedical Sciences Instrumentation Symposium
CityColorado Spring, CO, USA
Period4/25/884/26/88

Fingerprint

Hyperbaric chambers
Animals
Alcohols

ASJC Scopus subject areas

  • Hardware and Architecture

Cite this

Akers, T. K., & Belknap, J. (1988). Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS). In Biomedical Sciences Instrumentation (Vol. 24, pp. 225-230). Publ by Marcel Dekker.

Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS). / Akers, T. K.; Belknap, John.

Biomedical Sciences Instrumentation. Vol. 24 Publ by Marcel Dekker, 1988. p. 225-230.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Akers, TK & Belknap, J 1988, Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS). in Biomedical Sciences Instrumentation. vol. 24, Publ by Marcel Dekker, pp. 225-230, Proceedings of the Twenty-Fifth Annual Rocky Mountain Bioengineering Symposium and the Twenty-Fifth International ISA Biomedical Sciences Instrumentation Symposium, Colorado Spring, CO, USA, 4/25/88.
Akers TK, Belknap J. Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS). In Biomedical Sciences Instrumentation. Vol. 24. Publ by Marcel Dekker. 1988. p. 225-230
Akers, T. K. ; Belknap, John. / Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS). Biomedical Sciences Instrumentation. Vol. 24 Publ by Marcel Dekker, 1988. pp. 225-230
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