Abstract
The onset of hyperexcitability induced by HPNS in humans is easily determined by the disruption of simple motor tasks. We report here an adaptation of HIC for use in a sealed hyperbaric chamber on mice. Since these convulsions are elicited by lifting the mice by the tail, we developed a prototype apparatus which allows freedom of movement by the animals, yet the animals can be lifted at any desired interval by means of a fully proportional servo (Futaba FP-S48) actuated by a joy stick outside the chamber. Handling-induced convulsion scores were elevated by high pressure in heliox at pressures as low as 20 atmospheres, which is well below the thresholds for spontaneous clonic or tonic-clonic convulsions. This technique is especially useful in making direct comparisons between the hyperexcitability states associated with high pressure and those associated with alcohol and other drug withdrawal syndromes, where HIC is the predominant withdrawal sign.
| Original language | English (US) |
|---|---|
| Title of host publication | Biomedical Sciences Instrumentation |
| Publisher | Publ by Marcel Dekker |
| Pages | 225-230 |
| Number of pages | 6 |
| Volume | 24 |
| State | Published - 1988 |
| Externally published | Yes |
| Event | Proceedings of the Twenty-Fifth Annual Rocky Mountain Bioengineering Symposium and the Twenty-Fifth International ISA Biomedical Sciences Instrumentation Symposium - Colorado Spring, CO, USA Duration: Apr 25 1988 → Apr 26 1988 |
Other
| Other | Proceedings of the Twenty-Fifth Annual Rocky Mountain Bioengineering Symposium and the Twenty-Fifth International ISA Biomedical Sciences Instrumentation Symposium |
|---|---|
| City | Colorado Spring, CO, USA |
| Period | 4/25/88 → 4/26/88 |
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ASJC Scopus subject areas
- Hardware and Architecture
Cite this
Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS). / Akers, T. K.; Belknap, John.
Biomedical Sciences Instrumentation. Vol. 24 Publ by Marcel Dekker, 1988. p. 225-230.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Handling-induced convulsion (HIC) as a sensitive index of hyperexcitability associated with the high pressure nervous syndrome (HPNS)
AU - Akers, T. K.
AU - Belknap, John
PY - 1988
Y1 - 1988
N2 - The onset of hyperexcitability induced by HPNS in humans is easily determined by the disruption of simple motor tasks. We report here an adaptation of HIC for use in a sealed hyperbaric chamber on mice. Since these convulsions are elicited by lifting the mice by the tail, we developed a prototype apparatus which allows freedom of movement by the animals, yet the animals can be lifted at any desired interval by means of a fully proportional servo (Futaba FP-S48) actuated by a joy stick outside the chamber. Handling-induced convulsion scores were elevated by high pressure in heliox at pressures as low as 20 atmospheres, which is well below the thresholds for spontaneous clonic or tonic-clonic convulsions. This technique is especially useful in making direct comparisons between the hyperexcitability states associated with high pressure and those associated with alcohol and other drug withdrawal syndromes, where HIC is the predominant withdrawal sign.
AB - The onset of hyperexcitability induced by HPNS in humans is easily determined by the disruption of simple motor tasks. We report here an adaptation of HIC for use in a sealed hyperbaric chamber on mice. Since these convulsions are elicited by lifting the mice by the tail, we developed a prototype apparatus which allows freedom of movement by the animals, yet the animals can be lifted at any desired interval by means of a fully proportional servo (Futaba FP-S48) actuated by a joy stick outside the chamber. Handling-induced convulsion scores were elevated by high pressure in heliox at pressures as low as 20 atmospheres, which is well below the thresholds for spontaneous clonic or tonic-clonic convulsions. This technique is especially useful in making direct comparisons between the hyperexcitability states associated with high pressure and those associated with alcohol and other drug withdrawal syndromes, where HIC is the predominant withdrawal sign.
UR - http://www.scopus.com/inward/record.url?scp=0023824040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023824040&partnerID=8YFLogxK
M3 - Conference contribution
C2 - 3378100
AN - SCOPUS:0023824040
VL - 24
SP - 225
EP - 230
BT - Biomedical Sciences Instrumentation
PB - Publ by Marcel Dekker
ER -