Handheld optical coherence tomography angiography and ultra-wide-field optical coherence tomography in retinopathy of prematurity

John Campbell, Eric Nudleman, Jianlong Yang, Ou Tan, R. V.Paul Chan, Michael Chiang, David Huang, Gangjun Liu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

IMPORTANCE: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Optical coherence tomography (OCT) has improved the care of adults with vitreoretinal disease, and OCT angiography (OCTA) is demonstrating promise as a technique to visualize the retinal vasculature with lower risk and cost than fluorescein angiography. However, to date, there are no commercially available devices able to obtain ultra-wide-field OCT or OCTA images in neonates. OBJECTIVE: To obtain ultra-wide-field OCT and OCTA images in neonates with ROP using a prototype handheld OCT and OCTA device. DESIGN, SETTING, AND PARTICIPANTS: This observational case series was conducted from March 1 to April 1, 2017, in an academic medical center among 4 neonates with ROP in the neonatal intensive care unit and in the operating room. MAIN OUTCOMES AND MEASURES: Acquisition of wide-field OCT and OCTA images using a handheld prototype OCTA and ultra-wide-field OCT device. RESULTS: Images were obtained from 4 neonates (1 girl and 3 boys; mean age, 38 weeks’ postmenstrual age [range, 34-43 weeks]) with various stages of ROP: 3 in the neonatal intensive care unit and 1 in the operating room. The system can obtain noncontact en face OCT images and horizontal line scans with an approximately 40° field of view and up to 100° (ultra-wide-field) using a contact lens-based approach in a single 2-second scan. In addition, 20° × 20° (approximately 4 × 4-mm) OCTA scans were obtained in patients with ROP in a single 2-second scan. CONCLUSIONS AND RELEVANCE: Optical coherence tomography and OCTA are gaining popularity in pediatric retinal imaging. This study reports on OCTA and ultra-wide-field OCT images in 4 neonates with various stages of ROP that were obtained using a prototype handheld device. Additional studies will be needed to prove the clinical value of this technology.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalJAMA Ophthalmology
Volume135
Issue number9
DOIs
StatePublished - Sep 1 2017

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Retinopathy of Prematurity
Optical Coherence Tomography
Angiography
Newborn Infant
Equipment and Supplies
Neonatal Intensive Care Units
Operating Rooms
Fluorescein Angiography
Contact Lenses
Blindness
Pediatrics
Technology
Costs and Cost Analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Handheld optical coherence tomography angiography and ultra-wide-field optical coherence tomography in retinopathy of prematurity. / Campbell, John; Nudleman, Eric; Yang, Jianlong; Tan, Ou; Chan, R. V.Paul; Chiang, Michael; Huang, David; Liu, Gangjun.

In: JAMA Ophthalmology, Vol. 135, No. 9, 01.09.2017, p. 977-981.

Research output: Contribution to journalArticle

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