Handheld optical coherence tomography angiography

Jianlong Yang, Liang Liu, J. Peter Campbell, David Huang, Gangjun Liu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


We developed a handheld optical coherence tomography angiography (OCTA) system using a 100-kHz swept-source laser. The handheld probe weighs 0.4 kg and measures 20.6 × 12.8 × 4.6 cm3. The system has dedicated features for handheld operation. The probe is equipped with a mini iris camera for easy alignment. Real-time display of the en face OCT and cross-sectional OCT images in the system allows accurately locating the imaging target. Fast automatic focusing was achieved by an electrically tunable lens controlled by a golden-section search algorithm. An extended axial imaging range of 6 mm allows easy alignment. A registration algorithm using cross-correlation to register adjacent OCT B-frames with propagation from the central frame was used to effectively minimize motion artifacts in volumetric OCTA images captured in relatively short durations of 1 and 2.1 seconds. 2.5 × 2.5 mm (200 × 200 pixels) and 3.5 × 3.5 mm (300 × 300 pixels) retinal angiograms were demonstrated on two awake adult human subjects without the use of any mydriatic eye drops.

Original languageEnglish (US)
Article number#282470
Pages (from-to)2287-2300
Number of pages14
JournalBiomedical Optics Express
Issue number4
StatePublished - Apr 1 2017


  • Medical and biological imaging
  • Ophthalmic optics and devices
  • Optical coherence tomography

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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