Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain

Kalpana Mahesh Merchant, Margaret A. Miller, E. Alexandra Ashleigh, Daniel Dorsa

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The effects of an acute low dose of haloperidol on neurotensin mRNA-containing cells in rat forebrain was studied using in situ hybridization histochemistry. Within 1 h of a single dose of haloperidol (0.5 mg/kg) a nearly 3-fold increase in the number of cells that express the neurotensin/neuromedin N-encoding mRNA was observed in the dorsolateral striatum. However, the number of hybridization-positive cells did not appear to be affected in the nucleus accumbens, or the septal nuclei following treatment with the neuroleptic.

Original languageEnglish (US)
Pages (from-to)311-314
Number of pages4
JournalBrain Research
Volume540
Issue number1-2
DOIs
StatePublished - Feb 1 1991
Externally publishedYes

Fingerprint

Neostriatum
Neurotensin
neuromedin N
Haloperidol
Neurons
Septal Nuclei
Messenger RNA
Nucleus Accumbens
Brain
Prosencephalon
Antipsychotic Agents
In Situ Hybridization
Cell Count

Keywords

  • Basal ganglia
  • Haloperidol
  • Neuroleptic
  • Neurotensin mRNA

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain. / Merchant, Kalpana Mahesh; Miller, Margaret A.; Ashleigh, E. Alexandra; Dorsa, Daniel.

In: Brain Research, Vol. 540, No. 1-2, 01.02.1991, p. 311-314.

Research output: Contribution to journalArticle

Merchant, Kalpana Mahesh ; Miller, Margaret A. ; Ashleigh, E. Alexandra ; Dorsa, Daniel. / Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain. In: Brain Research. 1991 ; Vol. 540, No. 1-2. pp. 311-314.
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