Abstract
The effects of an acute low dose of haloperidol on neurotensin mRNA-containing cells in rat forebrain was studied using in situ hybridization histochemistry. Within 1 h of a single dose of haloperidol (0.5 mg/kg) a nearly 3-fold increase in the number of cells that express the neurotensin/neuromedin N-encoding mRNA was observed in the dorsolateral striatum. However, the number of hybridization-positive cells did not appear to be affected in the nucleus accumbens, or the septal nuclei following treatment with the neuroleptic.
Original language | English (US) |
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Pages (from-to) | 311-314 |
Number of pages | 4 |
Journal | Brain research |
Volume | 540 |
Issue number | 1-2 |
DOIs | |
State | Published - Feb 1 1991 |
Externally published | Yes |
Keywords
- Basal ganglia
- Haloperidol
- Neuroleptic
- Neurotensin mRNA
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology