Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain

Kalpana Mahesh Merchant, Margaret A. Miller, E. Alexandra Ashleigh, Daniel M. Dorsa

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The effects of an acute low dose of haloperidol on neurotensin mRNA-containing cells in rat forebrain was studied using in situ hybridization histochemistry. Within 1 h of a single dose of haloperidol (0.5 mg/kg) a nearly 3-fold increase in the number of cells that express the neurotensin/neuromedin N-encoding mRNA was observed in the dorsolateral striatum. However, the number of hybridization-positive cells did not appear to be affected in the nucleus accumbens, or the septal nuclei following treatment with the neuroleptic.

Original languageEnglish (US)
Pages (from-to)311-314
Number of pages4
JournalBrain research
Volume540
Issue number1-2
DOIs
StatePublished - Feb 1 1991

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Keywords

  • Basal ganglia
  • Haloperidol
  • Neuroleptic
  • Neurotensin mRNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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