Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males

M. Michele Murburg, David Paly, Charles W. Wilkinson, Richard C. Veith, Kenneth L. Malas, Daniel M. Dorsa

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

To investigate possible central dopaminergic regulation of betaendorphin-like immunoreactivity (βE-LI) and adrenocorticotropin (ACTH) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured βE-LI and cortisol for 120 minutes following injection. Haloperidol, but not placebo, produced significant increases in plasma βE-LI and cortisol. These findings suggest that central dopaminergic pathways such as the tuberohypophyseal system may participate in regulation of the secretion of βE and ACTH from the human pituitary.

Original languageEnglish (US)
Pages (from-to)373-381
Number of pages9
JournalLife Sciences
Volume39
Issue number4
DOIs
StatePublished - Jul 28 1986

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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