Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males

M. Michele Murburg, David Paly, Charles W. Wilkinson, Richard C. Veith, Kenneth L. Malas, Daniel Dorsa

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

To investigate possible central dopaminergic regulation of betaendorphin-like immunoreactivity (βE-LI) and adrenocorticotropin (ACTH) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured βE-LI and cortisol for 120 minutes following injection. Haloperidol, but not placebo, produced significant increases in plasma βE-LI and cortisol. These findings suggest that central dopaminergic pathways such as the tuberohypophyseal system may participate in regulation of the secretion of βE and ACTH from the human pituitary.

Original languageEnglish (US)
Pages (from-to)373-381
Number of pages9
JournalLife Sciences
Volume39
Issue number4
DOIs
StatePublished - Jul 28 1986
Externally publishedYes

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beta-Endorphin
Haloperidol
Adrenocorticotropic Hormone
Hydrocortisone
Plasmas
Placebos
Dopamine Antagonists
Injections

ASJC Scopus subject areas

  • Pharmacology

Cite this

Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males. / Michele Murburg, M.; Paly, David; Wilkinson, Charles W.; Veith, Richard C.; Malas, Kenneth L.; Dorsa, Daniel.

In: Life Sciences, Vol. 39, No. 4, 28.07.1986, p. 373-381.

Research output: Contribution to journalArticle

Michele Murburg, M. ; Paly, David ; Wilkinson, Charles W. ; Veith, Richard C. ; Malas, Kenneth L. ; Dorsa, Daniel. / Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males. In: Life Sciences. 1986 ; Vol. 39, No. 4. pp. 373-381.
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