TY - JOUR
T1 - Haloperidol does not alter expression of ethanol-induced conditioned place preference
AU - Cunningham, Christopher L.
AU - Malott, Dorcas H.
AU - Dickinson, Shelly D.
AU - Risinger, Fred O.
PY - 1992/9/28
Y1 - 1992/9/28
N2 - A recent experiment (Risinger et al., Psychopharmacology, 107 (1992) 453-456) has shown that haloperidol does not prevent acquisition of ethanol-induced conditioned place preference, suggesting that dopaminergic mechanisms do not mediate the primary rewarding properties of ethanol. The present experiment examined whether haloperidol would prevent the expression of conditioned reward to ethanol-paired stimuli using the place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP). A different stimulus was paired with saline. Before preference testing, different groups received one of three doses of haloperidol (0,0.05 or 0.1 mg/kg); ethanol was not given. Haloperidol produced a dose-dependent decrease in locomotor activity, but did not affect conditioned place preference. These results suggest that expression of ethanol-induced conditioned place preference is mediated by non-dopaminergic mechanisms.
AB - A recent experiment (Risinger et al., Psychopharmacology, 107 (1992) 453-456) has shown that haloperidol does not prevent acquisition of ethanol-induced conditioned place preference, suggesting that dopaminergic mechanisms do not mediate the primary rewarding properties of ethanol. The present experiment examined whether haloperidol would prevent the expression of conditioned reward to ethanol-paired stimuli using the place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP). A different stimulus was paired with saline. Before preference testing, different groups received one of three doses of haloperidol (0,0.05 or 0.1 mg/kg); ethanol was not given. Haloperidol produced a dose-dependent decrease in locomotor activity, but did not affect conditioned place preference. These results suggest that expression of ethanol-induced conditioned place preference is mediated by non-dopaminergic mechanisms.
KW - Conditioned place preference
KW - Dopamine system
KW - Ethanol
KW - Haloperidol
KW - Inbred mouse (DBA/2J)
KW - Reward
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U2 - 10.1016/S0166-4328(05)80282-7
DO - 10.1016/S0166-4328(05)80282-7
M3 - Article
C2 - 1449638
AN - SCOPUS:0026658404
SN - 0166-4328
VL - 50
SP - 1
EP - 5
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1-2
ER -