Hallucinations and Development of Dementia in Parkinson's Disease

Wojciech Gryc; Kathryn A. Roberts; Cyrus P. Zabetian; Daniel Weintraub; John Q. Trojanowski; Joseph F. Quinn; Amie L. Hiller; Kathryn A. Chung; Kathleen L. Poston; Laurice Yang; Shu Ching Hu; Karen L. Edwards; Thomas J. Montine; Brenna A. Cholerton

doi:10.3233/JPD-202116

Hallucinations and Development of Dementia in Parkinson's Disease

Wojciech Gryc, Kathryn A. Roberts, Cyrus P. Zabetian, Daniel Weintraub, John Q. Trojanowski, Joseph F. Quinn, Amie L. Hiller, Kathryn A. Chung, Kathleen L. Poston, Laurice Yang, Shu Ching Hu, Karen L. Edwards, Thomas J. Montine, Brenna A. Cholerton

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Neuropsychiatric symptoms are common in Parkinson's disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n=696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p<0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n=444; p=0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD.

Original language	English (US)
Pages (from-to)	1643-1648
Number of pages	6
Journal	Journal of Parkinson's Disease
Volume	10
Issue number	4
DOIs	https://doi.org/10.3233/JPD-202116
State	Published - 2020

Keywords

Behavioral symptoms
Parkinson's disease
cognition
dementia
hallucinations

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience

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10.3233/JPD-202116

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title = "Hallucinations and Development of Dementia in Parkinson's Disease",

abstract = "Neuropsychiatric symptoms are common in Parkinson's disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n=696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p<0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n=444; p=0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD.",

keywords = "Behavioral symptoms, Parkinson's disease, cognition, dementia, hallucinations",

author = "Wojciech Gryc and Roberts, {Kathryn A.} and Zabetian, {Cyrus P.} and Daniel Weintraub and Trojanowski, {John Q.} and Quinn, {Joseph F.} and Hiller, {Amie L.} and Chung, {Kathryn A.} and Poston, {Kathleen L.} and Laurice Yang and Hu, {Shu Ching} and Edwards, {Karen L.} and Montine, {Thomas J.} and Cholerton, {Brenna A.}",

year = "2020",

doi = "10.3233/JPD-202116",

language = "English (US)",

volume = "10",

pages = "1643--1648",

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AU - Gryc, Wojciech

AU - Roberts, Kathryn A.

AU - Zabetian, Cyrus P.

AU - Weintraub, Daniel

AU - Trojanowski, John Q.

AU - Quinn, Joseph F.

AU - Hiller, Amie L.

AU - Chung, Kathryn A.

AU - Poston, Kathleen L.

AU - Yang, Laurice

AU - Hu, Shu Ching

AU - Edwards, Karen L.

AU - Montine, Thomas J.

AU - Cholerton, Brenna A.

PY - 2020

Y1 - 2020

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AB - Neuropsychiatric symptoms are common in Parkinson's disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n=696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p<0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n=444; p=0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD.

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KW - Parkinson's disease

KW - cognition

KW - dementia

KW - hallucinations

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Hallucinations and Development of Dementia in Parkinson's Disease

Abstract

Keywords

ASJC Scopus subject areas

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