@article{fef3fbfb76e24e0e9cdcc42620ca7b41,
title = "Hallucinations and Development of Dementia in Parkinson's Disease",
abstract = "Neuropsychiatric symptoms are common in Parkinson's disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n=696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p<0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n=444; p=0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD. ",
keywords = "Behavioral symptoms, Parkinson's disease, cognition, dementia, hallucinations",
author = "Wojciech Gryc and Roberts, {Kathryn A.} and Zabetian, {Cyrus P.} and Daniel Weintraub and Trojanowski, {John Q.} and Quinn, {Joseph F.} and Hiller, {Amie L.} and Chung, {Kathryn A.} and Poston, {Kathleen L.} and Laurice Yang and Hu, {Shu Ching} and Edwards, {Karen L.} and Montine, {Thomas J.} and Cholerton, {Brenna A.}",
note = "Funding Information: This work was supported by grants from the National Institutes of Neurological Disorders and Stroke (P50 NS062684) and Department of Veterans Affairs (101 CX001702). Data contributed by the current project Center On Alpha-Synuclein Strains in Alzheimer{\textquoteright}s Disease & Related Dementias at the Perelman School of Medicine at the University of Pennsylvania (U19 AG062418, Trojanowski JQ – PI; Weintraub D; Chen-Plotkin A; Dahodwala N; Morley JF; Duda JE) and former Morris K. Udall Center at the Perelman School of Medicine at the University of Pennsylvania (P50 NS053488, Tro-janowski JQ – PI). Dr. Gryc and Dr. Roberts were supported by the Veterans Affairs Advanced Fellowship Program in Parkinson{\textquoteright}s Disease. We sincerely thank all of the individuals who participated in this study. Publisher Copyright: {\textcopyright} 2020 - IOS Press and the authors. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.3233/JPD-202116",
language = "English (US)",
volume = "10",
pages = "1643--1648",
journal = "Journal of Parkinson's Disease",
issn = "1877-7171",
publisher = "IOS Press",
number = "4",
}