Hallucinations and Development of Dementia in Parkinson's Disease

Wojciech Gryc, Kathryn A. Roberts, Cyrus P. Zabetian, Daniel Weintraub, John Q. Trojanowski, Joseph F. Quinn, Amie L. Hiller, Kathryn A. Chung, Kathleen L. Poston, Laurice Yang, Shu Ching Hu, Karen L. Edwards, Thomas J. Montine, Brenna A. Cholerton

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Neuropsychiatric symptoms are common in Parkinson's disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n=696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p<0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n=444; p=0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD.

Original languageEnglish (US)
Pages (from-to)1643-1648
Number of pages6
JournalJournal of Parkinson's Disease
Volume10
Issue number4
DOIs
StatePublished - 2020

Keywords

  • Behavioral symptoms
  • Parkinson's disease
  • cognition
  • dementia
  • hallucinations

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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