Hallervorden-Spatz Syndrome (PKAN)

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Hallervorden-Spatz syndrome is a genetic disorder associated with brain iron accumulation. The features include dystonia, dysarthria, pigmentary retinopathy, and characteristic MRI changes. Mutations in the gene encoding pantothenate kinase 2 underlie this disorder, now referred to as pantothenate kinase-associated neurodegeneration or PKAN. Although treatment remains palliative, rational therapeutics are being explored.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Number of pages3
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
StatePublished - Jan 1 2010


  • Axonal spheroids
  • Brain iron
  • Coenzyme A
  • Globus pallidus
  • Hallervorden-Spatz syndrome
  • PANK2
  • Pantothenate kinase-associated neurodegeneration (PKAN)

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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