Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells

Che Ming Jack Hu, Sharmeela Kaushal, Hop S.Tran Cao, Santosh Aryal, Marta Sartor, Sadik Esener, Michael Bouvet, Liangfang Zhang

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a drug delivery vehicle releases a large payload upon tumor localization, is thus a promising alternative strategy against this lethal disease. Herein, we synthesize anti-carcinoembryonic antigen (CEA) half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding nontargeted nanoparticles.

Original languageEnglish (US)
Pages (from-to)914-920
Number of pages7
JournalMolecular Pharmaceutics
Volume7
Issue number3
DOIs
StatePublished - Jun 7 2010

Keywords

  • Carcinoembryonic antigen
  • Half-antibody
  • Lipid-polymer nanoparticles
  • Pancreatic cancer
  • Targeted drug delivery

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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