H-Y antigen mosaicism in the gonad of a 46,XX true hermaphrodite

S. J. Winters, S. S. Wachtel, B. J. White, G. C. Koo, N. Javadpour, Donald (Lynn) Loriaux, R. J. Sherins

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

To clarify the mechanism for the coexistence of ovarian and testicular tissue in the 46,XX true hermaphrodite, we studied a 20-year-old phenotypic male with gynecomastia and elevated serum concentrations of estradiol in whom an ovotestis was discovered upon scrotal exploration. Y chromosomal material could not be detected by fluorescent Y-body analysis or Giemsa-banding technics in cells cultured from peripheral blood, breast or forearm skin or the ovarian or testicular portions of the ovotestis. However, serologic testing, using the sperm cytotoxicity assay, revealed that cells cultured from the testicular portion of the ovotestis were H-Y antigen positive whereas cells cultured from the ovarian portion were H-Y antigen negative. These observations indicate that the ovotestis arises from an H-Y +/H-Y - mosaic primordium.

Original languageEnglish (US)
Pages (from-to)745-749
Number of pages5
JournalNew England Journal of Medicine
Volume300
Issue number14
StatePublished - 1979
Externally publishedYes

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H-Y Antigen
Mosaicism
Gonads
Cultured Cells
Gynecomastia
Forearm
Spermatozoa
Estradiol
Breast
Skin
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Winters, S. J., Wachtel, S. S., White, B. J., Koo, G. C., Javadpour, N., Loriaux, D. L., & Sherins, R. J. (1979). H-Y antigen mosaicism in the gonad of a 46,XX true hermaphrodite. New England Journal of Medicine, 300(14), 745-749.

H-Y antigen mosaicism in the gonad of a 46,XX true hermaphrodite. / Winters, S. J.; Wachtel, S. S.; White, B. J.; Koo, G. C.; Javadpour, N.; Loriaux, Donald (Lynn); Sherins, R. J.

In: New England Journal of Medicine, Vol. 300, No. 14, 1979, p. 745-749.

Research output: Contribution to journalArticle

Winters, SJ, Wachtel, SS, White, BJ, Koo, GC, Javadpour, N, Loriaux, DL & Sherins, RJ 1979, 'H-Y antigen mosaicism in the gonad of a 46,XX true hermaphrodite', New England Journal of Medicine, vol. 300, no. 14, pp. 745-749.
Winters SJ, Wachtel SS, White BJ, Koo GC, Javadpour N, Loriaux DL et al. H-Y antigen mosaicism in the gonad of a 46,XX true hermaphrodite. New England Journal of Medicine. 1979;300(14):745-749.
Winters, S. J. ; Wachtel, S. S. ; White, B. J. ; Koo, G. C. ; Javadpour, N. ; Loriaux, Donald (Lynn) ; Sherins, R. J. / H-Y antigen mosaicism in the gonad of a 46,XX true hermaphrodite. In: New England Journal of Medicine. 1979 ; Vol. 300, No. 14. pp. 745-749.
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