@article{2c75b7ff18964fbcb36ee973f3d79453,
title = "Gut microbiome pattern reflects healthy ageing and predicts survival in humans",
abstract = "The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age. We leverage three independent cohorts comprising over 9,000 individuals and find that compositional uniqueness is strongly associated with microbially produced amino acid derivatives circulating in the bloodstream. In older age (over ~80 years), healthy individuals show continued microbial drift towards a unique compositional state, whereas this drift is absent in less healthy individuals. The identified microbiome pattern of healthy ageing is characterized by a depletion of core genera found across most humans, primarily Bacteroides. Retaining a high Bacteroides dominance into older age, or having a low gut microbiome uniqueness measure, predicts decreased survival in a 4-year follow-up. Our analysis identifies increasing compositional uniqueness of the gut microbiome as a component of healthy ageing, which is characterized by distinct microbial metabolic outputs in the blood.",
author = "Tomasz Wilmanski and Christian Diener and Noa Rappaport and Sushmita Patwardhan and Jack Wiedrick and Jodi Lapidus and Earls, {John C.} and Anat Zimmer and Gustavo Glusman and Max Robinson and Yurkovich, {James T.} and Kado, {Deborah M.} and Cauley, {Jane A.} and Joseph Zmuda and Lane, {Nancy E.} and Magis, {Andrew T.} and Lovejoy, {Jennifer C.} and Leroy Hood and Gibbons, {Sean M.} and Orwoll, {Eric S.} and Price, {Nathan D.}",
note = "Funding Information: We thank C. Funk for helpful discussions throughout the course of this project. We also thank J. Dougherty and M. Brunkow for their coordination efforts. This work was supported by the M.J. Murdock Charitable Trust (to L.H. and N.D.P.), Arivale and a generous gift from C. Ellison (T.W.). S.M.G., C.D. and S.P. were supported by a Washington Research Foundation Distinguished Investigator Award and by start-up funds from the Institute for Systems Biology. Further support came from the National Academy of Medicine Catalyst Award (to N.D.P., S.M.G., L.H. and E.S.O.) and a National Institutes of Health (NIH) grant (no. U19AG023122) awarded by the National Institute on Aging (NIA). The MrOS Study is supported by NIH funding. The following institutes provide support: the NIA, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS) and the NIH Roadmap for Medical Research under the following grant nos.: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160 and UL1 TR000128. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2021",
month = feb,
doi = "10.1038/s42255-021-00348-0",
language = "English (US)",
volume = "3",
pages = "274--286",
journal = "Nature Metabolism",
issn = "2522-5812",
publisher = "Springer Berlin",
number = "2",
}