Guidelines on genetic evaluation and management of lynch syndrome: A consensus statement by the US multi-society task force on colorectal cancer

Francis M. Giardiello, John I. Allen, Jennifer E. Axilbund, C. Richard Boland, Carol A. Burke, Randall W. Burt, James M. Church, Jason A. Dominitz, David A. Johnson, Tonya Kaltenbach, Theodore R. Levin, David Lieberman, Douglas J. Robertson, Sapna Syngal, Douglas K. Rex

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3,4,5,6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.

Original languageEnglish (US)
Pages (from-to)1159-1179
Number of pages21
JournalAmerican Journal of Gastroenterology
Volume109
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Advisory Committees
Colorectal Neoplasms
Consensus
Guidelines
Genetic Testing
Pedigree
Health Personnel
Endoscopy
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Guidelines on genetic evaluation and management of lynch syndrome : A consensus statement by the US multi-society task force on colorectal cancer. / Giardiello, Francis M.; Allen, John I.; Axilbund, Jennifer E.; Boland, C. Richard; Burke, Carol A.; Burt, Randall W.; Church, James M.; Dominitz, Jason A.; Johnson, David A.; Kaltenbach, Tonya; Levin, Theodore R.; Lieberman, David; Robertson, Douglas J.; Syngal, Sapna; Rex, Douglas K.

In: American Journal of Gastroenterology, Vol. 109, No. 8, 2014, p. 1159-1179.

Research output: Contribution to journalArticle

Giardiello, FM, Allen, JI, Axilbund, JE, Boland, CR, Burke, CA, Burt, RW, Church, JM, Dominitz, JA, Johnson, DA, Kaltenbach, T, Levin, TR, Lieberman, D, Robertson, DJ, Syngal, S & Rex, DK 2014, 'Guidelines on genetic evaluation and management of lynch syndrome: A consensus statement by the US multi-society task force on colorectal cancer', American Journal of Gastroenterology, vol. 109, no. 8, pp. 1159-1179. https://doi.org/10.1038/ajg.2014.186
Giardiello, Francis M. ; Allen, John I. ; Axilbund, Jennifer E. ; Boland, C. Richard ; Burke, Carol A. ; Burt, Randall W. ; Church, James M. ; Dominitz, Jason A. ; Johnson, David A. ; Kaltenbach, Tonya ; Levin, Theodore R. ; Lieberman, David ; Robertson, Douglas J. ; Syngal, Sapna ; Rex, Douglas K. / Guidelines on genetic evaluation and management of lynch syndrome : A consensus statement by the US multi-society task force on colorectal cancer. In: American Journal of Gastroenterology. 2014 ; Vol. 109, No. 8. pp. 1159-1179.
@article{929d7df34b174011bce8cb7f7cbdecd9,
title = "Guidelines on genetic evaluation and management of lynch syndrome: A consensus statement by the US multi-society task force on colorectal cancer",
abstract = "The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3,4,5,6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.",
author = "Giardiello, {Francis M.} and Allen, {John I.} and Axilbund, {Jennifer E.} and Boland, {C. Richard} and Burke, {Carol A.} and Burt, {Randall W.} and Church, {James M.} and Dominitz, {Jason A.} and Johnson, {David A.} and Tonya Kaltenbach and Levin, {Theodore R.} and David Lieberman and Robertson, {Douglas J.} and Sapna Syngal and Rex, {Douglas K.}",
year = "2014",
doi = "10.1038/ajg.2014.186",
language = "English (US)",
volume = "109",
pages = "1159--1179",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Guidelines on genetic evaluation and management of lynch syndrome

T2 - A consensus statement by the US multi-society task force on colorectal cancer

AU - Giardiello, Francis M.

AU - Allen, John I.

AU - Axilbund, Jennifer E.

AU - Boland, C. Richard

AU - Burke, Carol A.

AU - Burt, Randall W.

AU - Church, James M.

AU - Dominitz, Jason A.

AU - Johnson, David A.

AU - Kaltenbach, Tonya

AU - Levin, Theodore R.

AU - Lieberman, David

AU - Robertson, Douglas J.

AU - Syngal, Sapna

AU - Rex, Douglas K.

PY - 2014

Y1 - 2014

N2 - The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3,4,5,6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.

AB - The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3,4,5,6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.

UR - http://www.scopus.com/inward/record.url?scp=84905595139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905595139&partnerID=8YFLogxK

U2 - 10.1038/ajg.2014.186

DO - 10.1038/ajg.2014.186

M3 - Article

C2 - 25070057

AN - SCOPUS:84905595139

VL - 109

SP - 1159

EP - 1179

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 8

ER -