Guam ALS/parkinsonism-dementia: A long-latency neurotoxic disorder caused by 'slow toxin(s)' in food?

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Parkinsonism (P) with progressive dementia (D) of the Alzheimer type is recognized as a clinical variant of a form of amyotrophic lageral sclerosis (ALS) that has occurred in high incidence among the Chamorro people of the islands of Guam and Rota in the Marianas chain of Micronesia. The declining annual incidence, upward shifting of the age of onset, narrowing of the sex ratio, and occurrence of the disease among non-Chamorros, point to a disappearing environmental causation peculiar to the traditional culture of these islands. Evidence is presented in support of the proposal that heavy use of certain toxic plants, notably cycads, a traditional source of food and medicine for the Chamorro people, plays an important etiological role. Clinical and epidemiological approaches are offered to test for a relationship between ALS/P-D and long-latency plant toxicity.

Original languageEnglish (US)
Pages (from-to)347-357
Number of pages11
JournalCanadian Journal of Neurological Sciences
Volume14
Issue number3 SUPPL.
StatePublished - 1987
Externally publishedYes

Fingerprint

Neurotoxicity Syndromes
Guam
Parkinsonian Disorders
Sclerosis
Islands
Dementia
Micronesia
Toxic Plants
Food
Incidence
Sex Ratio
Age of Onset
Causality
Alzheimer Disease
Medicine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

@article{160c2e6d186646b09178ea375c66a147,
title = "Guam ALS/parkinsonism-dementia: A long-latency neurotoxic disorder caused by 'slow toxin(s)' in food?",
abstract = "Parkinsonism (P) with progressive dementia (D) of the Alzheimer type is recognized as a clinical variant of a form of amyotrophic lageral sclerosis (ALS) that has occurred in high incidence among the Chamorro people of the islands of Guam and Rota in the Marianas chain of Micronesia. The declining annual incidence, upward shifting of the age of onset, narrowing of the sex ratio, and occurrence of the disease among non-Chamorros, point to a disappearing environmental causation peculiar to the traditional culture of these islands. Evidence is presented in support of the proposal that heavy use of certain toxic plants, notably cycads, a traditional source of food and medicine for the Chamorro people, plays an important etiological role. Clinical and epidemiological approaches are offered to test for a relationship between ALS/P-D and long-latency plant toxicity.",
author = "Peter Spencer",
year = "1987",
language = "English (US)",
volume = "14",
pages = "347--357",
journal = "Canadian Journal of Neurological Sciences",
issn = "0317-1671",
publisher = "Canadian Journal of Neurological Sciences",
number = "3 SUPPL.",

}

TY - JOUR

T1 - Guam ALS/parkinsonism-dementia

T2 - A long-latency neurotoxic disorder caused by 'slow toxin(s)' in food?

AU - Spencer, Peter

PY - 1987

Y1 - 1987

N2 - Parkinsonism (P) with progressive dementia (D) of the Alzheimer type is recognized as a clinical variant of a form of amyotrophic lageral sclerosis (ALS) that has occurred in high incidence among the Chamorro people of the islands of Guam and Rota in the Marianas chain of Micronesia. The declining annual incidence, upward shifting of the age of onset, narrowing of the sex ratio, and occurrence of the disease among non-Chamorros, point to a disappearing environmental causation peculiar to the traditional culture of these islands. Evidence is presented in support of the proposal that heavy use of certain toxic plants, notably cycads, a traditional source of food and medicine for the Chamorro people, plays an important etiological role. Clinical and epidemiological approaches are offered to test for a relationship between ALS/P-D and long-latency plant toxicity.

AB - Parkinsonism (P) with progressive dementia (D) of the Alzheimer type is recognized as a clinical variant of a form of amyotrophic lageral sclerosis (ALS) that has occurred in high incidence among the Chamorro people of the islands of Guam and Rota in the Marianas chain of Micronesia. The declining annual incidence, upward shifting of the age of onset, narrowing of the sex ratio, and occurrence of the disease among non-Chamorros, point to a disappearing environmental causation peculiar to the traditional culture of these islands. Evidence is presented in support of the proposal that heavy use of certain toxic plants, notably cycads, a traditional source of food and medicine for the Chamorro people, plays an important etiological role. Clinical and epidemiological approaches are offered to test for a relationship between ALS/P-D and long-latency plant toxicity.

UR - http://www.scopus.com/inward/record.url?scp=0023253372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023253372&partnerID=8YFLogxK

M3 - Article

C2 - 3315142

AN - SCOPUS:0023253372

VL - 14

SP - 347

EP - 357

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

SN - 0317-1671

IS - 3 SUPPL.

ER -