GSK-3β: A bifunctional role in cell death pathways

Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry Jaboin, Dennis E. Hallahan, Dinesh Thotala

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118 Scopus citations

Abstract

Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular functions. GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors that determine the survival or death of the organism. Secondary to the role of GSK-3β in various diseases including Alzheimers disease, inflammation, diabetes, and cancer, small molecule inhibitors of GSK-3β are gaining significant attention. This paper is primarily focused on addressing the bifunctional or conflicting roles of GSK-3β in both the promotion of cell survival and of apoptosis. GSK-3β has emerged as an important molecular target for drug development.

Original languageEnglish (US)
Article number930710
JournalInternational Journal of Cell Biology
DOIs
Publication statusPublished - 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

Cite this

Jacobs, K. M., Bhave, S. R., Ferraro, D. J., Jaboin, J., Hallahan, D. E., & Thotala, D. (2012). GSK-3β: A bifunctional role in cell death pathways. International Journal of Cell Biology, [930710]. https://doi.org/10.1155/2012/930710