Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation

Anand Venkataraman, Daniel J. Coleman, Daniel J. Nevrivy, Tulley Long, Chrissa Kioussi, Arup K. Indra, Mark Leid

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Grp1-associated scaffold protein (Grasp), the product of a retinoic acid-induced gene in P19 embryonal carcinoma cells, is expressed primarily in brain, heart, and lung of the mouse. We report herein that Grasp transcripts are also found in mouse skin in which the Grasp gene is robustly induced following acute ultraviolet-B (UVB) exposure. Grasp-/- mice were found to exhibit delayed epidermal proliferation and a blunted apoptotic response after acute UVB exposure. Immunohistochemical analyses revealed that the nuclear residence time of the tumor suppressor protein p53 was reduced in Grasp -/- mice after UVB exposure. Taken together, our results suggest that a physiological role of Grasp may be to regulate skin homeostasis after UVB exposure, potentially by influencing p53-mediated apoptotic responses in skin.

Original languageEnglish (US)
Pages (from-to)531-540
Number of pages10
JournalPhotochemical and Photobiological Sciences
Volume13
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation'. Together they form a unique fingerprint.

Cite this